The TBD (1,3,5-triazabicyclodec-5-ene) assisted three-component carbonylation of pyridine-2-methana- mines is documented by means of CO2 as a benign CO surrogate. The redox-neutral methodology enables the re- alization of densely functionalized imidazo-pyridinones in high yields (up to 93%) and excellent chemoselectivity. Combined computational and experimental investigations revealed an unprecedented RCOCl/TBD concerted electro- philic activation of carbon dioxide.
Redox-Neutral Metal-Free Three-Component Carbonylative Dearomatization of Pyridine Derivatives with CO2
Alessandro CerveriMethodology
;Magda MonariMethodology
;Marco LombardoConceptualization
;Marco Bandini
Conceptualization
2019
Abstract
The TBD (1,3,5-triazabicyclodec-5-ene) assisted three-component carbonylation of pyridine-2-methana- mines is documented by means of CO2 as a benign CO surrogate. The redox-neutral methodology enables the re- alization of densely functionalized imidazo-pyridinones in high yields (up to 93%) and excellent chemoselectivity. Combined computational and experimental investigations revealed an unprecedented RCOCl/TBD concerted electro- philic activation of carbon dioxide.File in questo prodotto:
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