The enzyme nicotinamide nucleotide transhydrogenase (NNT) transfers hydride from NADH to NADP+ coupled to H+ translocation across the inner mitochondrial membrane. In a recent study, Kampjut and Sazanov reveal that the bifunctional NNT mechanism rules the NAD(P)+/NAD(P)H interconversion ratio, which in turn regulates antioxidant defense and sirtuin actions.
Nesci S., Trombetti F., Pagliarani A. (2020). Nicotinamide Nucleotide Transhydrogenase as a Sensor of Mitochondrial Biology. TRENDS IN CELL BIOLOGY, 30(1), 1-3 [10.1016/j.tcb.2019.11.001].
Nicotinamide Nucleotide Transhydrogenase as a Sensor of Mitochondrial Biology
Nesci S.
;Trombetti F.;Pagliarani A.
2020
Abstract
The enzyme nicotinamide nucleotide transhydrogenase (NNT) transfers hydride from NADH to NADP+ coupled to H+ translocation across the inner mitochondrial membrane. In a recent study, Kampjut and Sazanov reveal that the bifunctional NNT mechanism rules the NAD(P)+/NAD(P)H interconversion ratio, which in turn regulates antioxidant defense and sirtuin actions.File in questo prodotto:
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