The enzyme nicotinamide nucleotide transhydrogenase (NNT) transfers hydride from NADH to NADP+ coupled to H+ translocation across the inner mitochondrial membrane. In a recent study, Kampjut and Sazanov reveal that the bifunctional NNT mechanism rules the NAD(P)+/NAD(P)H interconversion ratio, which in turn regulates antioxidant defense and sirtuin actions.

Nicotinamide Nucleotide Transhydrogenase as a Sensor of Mitochondrial Biology

Nesci S.
;
Trombetti F.;Pagliarani A.
2020

Abstract

The enzyme nicotinamide nucleotide transhydrogenase (NNT) transfers hydride from NADH to NADP+ coupled to H+ translocation across the inner mitochondrial membrane. In a recent study, Kampjut and Sazanov reveal that the bifunctional NNT mechanism rules the NAD(P)+/NAD(P)H interconversion ratio, which in turn regulates antioxidant defense and sirtuin actions.
Nesci S.; Trombetti F.; Pagliarani A.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/711191
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