Substituted hydroxy-benzofurans are easily accessible by treatment of resorcinols and 1,2-diaza-1,3-dienes (DDs) under acidic conditions. The reaction happens through an uncommon Michael reaction between aromatic derivatives as aromatic C(sp2)-H nucleophiles and DDs as acceptors. Also, the behavior of different phenols and 2-naphthol was investigated.
Mari G., Ciccolini C., De Crescentini L., Favi G., Santeusanio S., Mancinelli M., et al. (2019). Metal and oxidant-free Brønsted acid-mediated cascade reaction to substituted benzofurans. JOURNAL OF ORGANIC CHEMISTRY, 84(17), 10814-10824 [10.1021/acs.joc.9b01363].
Metal and oxidant-free Brønsted acid-mediated cascade reaction to substituted benzofurans
Mancinelli M.;
2019
Abstract
Substituted hydroxy-benzofurans are easily accessible by treatment of resorcinols and 1,2-diaza-1,3-dienes (DDs) under acidic conditions. The reaction happens through an uncommon Michael reaction between aromatic derivatives as aromatic C(sp2)-H nucleophiles and DDs as acceptors. Also, the behavior of different phenols and 2-naphthol was investigated.File in questo prodotto:
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