Many potential therapeutic compounds for brain diseases fail to reach their molecular targets due to the impermeability of the blood-brain barrier, limiting their clinical development. Nanotechnology-based approaches might improve compounds pharmacokinetics by enhancing binding to the cerebrovascular endothelium and translocation into the brain. Adsorption of apolipoprotein E4 onto polysorbate 80-stabilized nanoparticles to produce a protein corona allows the specific targeting of cerebrovascular endothelium. This strategy increased nanoparticle translocation into brain parenchyma, and improved brain nanoparticle accumulation 3-fold compared to undecorated particles (119.8 vs 40.5 picomoles). Apolipoprotein decorated nanoparticles have high clinical translational potential and may improve the development of nanotechnology-based medicine for a variety of neurological diseases. (C) 2017 Elsevier Inc. All rights reserved.
Artificial apolipoprotein corona enables nanoparticle brain targeting / Dal Magro R.; Albertini B.; Beretta S.; Rigolio R.; Donzelli E.; Chiorazzi A.; Ricci M.; Blasi P.; Sancini G.. - In: NANOMEDICINE. - ISSN 1549-9634. - STAMPA. - 14:2(2018), pp. 429-438. [10.1016/j.nano.2017.11.008]
Artificial apolipoprotein corona enables nanoparticle brain targeting
Blasi P.
Conceptualization
;
2018
Abstract
Many potential therapeutic compounds for brain diseases fail to reach their molecular targets due to the impermeability of the blood-brain barrier, limiting their clinical development. Nanotechnology-based approaches might improve compounds pharmacokinetics by enhancing binding to the cerebrovascular endothelium and translocation into the brain. Adsorption of apolipoprotein E4 onto polysorbate 80-stabilized nanoparticles to produce a protein corona allows the specific targeting of cerebrovascular endothelium. This strategy increased nanoparticle translocation into brain parenchyma, and improved brain nanoparticle accumulation 3-fold compared to undecorated particles (119.8 vs 40.5 picomoles). Apolipoprotein decorated nanoparticles have high clinical translational potential and may improve the development of nanotechnology-based medicine for a variety of neurological diseases. (C) 2017 Elsevier Inc. All rights reserved.| File | Dimensione | Formato | |
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Nanomedicine 14 (2018) 429–438.pdf
Open Access dal 01/03/2019
Descrizione: Accepted manuscript
Tipo:
Postprint
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Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale - Non opere derivate (CCBYNCND)
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1.71 MB
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Adobe PDF
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