The synthesis of 1,3,4-trisubstituted pyrroles via visible-light mediated photoredox catalyzed condensation of arylazides and aldehydes has been reported herein. The methodology avoids the use of stoichiometric oxidants and provides the corresponding N-containing arenes in good yields (up to 78%) and mild conditions. Mechanistic rationale is provided via a dedicated and combined spectroscopic/experimental investigations.
Yang Liu, A.P. (2019). Visible-Light-Driven Synthesis of 1,3,4-Trisubstituted Pyrroles from Aryl Azides. ORGANIC LETTERS, 21(19), 7782-7786 [10.1021/acs.orglett.9b02731].
Visible-Light-Driven Synthesis of 1,3,4-Trisubstituted Pyrroles from Aryl Azides
Yang LiuMethodology
;Adriano ParodiMethodology
;Simone BattaglioliMembro del Collaboration Group
;Magda MonariMethodology
;Marco Bandini
Conceptualization
2019
Abstract
The synthesis of 1,3,4-trisubstituted pyrroles via visible-light mediated photoredox catalyzed condensation of arylazides and aldehydes has been reported herein. The methodology avoids the use of stoichiometric oxidants and provides the corresponding N-containing arenes in good yields (up to 78%) and mild conditions. Mechanistic rationale is provided via a dedicated and combined spectroscopic/experimental investigations.File in questo prodotto:
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