Patients harboring rearrangements of the ROS1 gene are eligible for first-line therapy with Crizotinib, which represents the best available treatment option. Diagnostic criteria, based on break-apart fluorescence in situ hybridization, were mirrored from ALK by analogy and include tumors with 5' deletions. However, the probability of response to Crizotinib in patients with 5' deletion in ROS1 is unknown given the rarity of this condition.

Clinical significance of ROS1 5’ deletions in non-small cell lung cancer

Capizzi E.;Dall'Olio F. G.;Fiorentino M.
;
Ardizzoni A.
2019

Abstract

Patients harboring rearrangements of the ROS1 gene are eligible for first-line therapy with Crizotinib, which represents the best available treatment option. Diagnostic criteria, based on break-apart fluorescence in situ hybridization, were mirrored from ALK by analogy and include tumors with 5' deletions. However, the probability of response to Crizotinib in patients with 5' deletion in ROS1 is unknown given the rarity of this condition.
2019
Capizzi E.; Dall'Olio F.G.; Gruppioni E.; Sperandi F.; Altimari A.; Giunchi F.; Fiorentino M.; Ardizzoni A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/697148
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