Programmed death ligand 1 (PD-L1) is a protein which, when interacting with its receptor programmed death 1, acts as a negative regulator of the antitumor T-cell-mediated immune response. The prognostic value of PD-L1 expression in renal cell carcinoma (RCC) has been controversial. In this study, the prognostic value of PD-L1 expression in RCC was evaluated by analyzing PD-L1 immunoreactivity in tumor cells and tumor-infiltrating immune cells (TIICs) in 346 RCC patients with long-term follow-up. PD-L1 positivity in tumor cells was associated with higher World Health Organization nucleolar grade (P<0.001), recurrence (P=0.011), and death due to RCC (P=0.031). PD-L1 positivity in TIICs was associated with higher nucleolar grade (P<0.001), higher T-stage (P=0.031), higher N-stage (P=0.01), recurrence (P=0.007), and death due to RCC (P=0.001). A significant positive association of time to cancer-specific death with both PD-L1-positive tumor cells and TIICs were also found. The data indicate that RCC patients with PD-L1-positive tumor cells and TIICs are at significant risk for cancer progression and the expression may be used as a complementary prognostic factor in the management of RCC patients.

Carlsson J., Sundqvist P., Kosuta V., Falt A., Giunchi F., Fiorentino M., et al. (2020). PD-L1 Expression is Associated with Poor Prognosis in Renal Cell Carcinoma. APPLIED IMMUNOHISTOCHEMISTRY AND MOLECULAR MORPHOLOGY, 28(3), 213-220 [10.1097/PAI.0000000000000766].

PD-L1 Expression is Associated with Poor Prognosis in Renal Cell Carcinoma

Fiorentino M.;
2020

Abstract

Programmed death ligand 1 (PD-L1) is a protein which, when interacting with its receptor programmed death 1, acts as a negative regulator of the antitumor T-cell-mediated immune response. The prognostic value of PD-L1 expression in renal cell carcinoma (RCC) has been controversial. In this study, the prognostic value of PD-L1 expression in RCC was evaluated by analyzing PD-L1 immunoreactivity in tumor cells and tumor-infiltrating immune cells (TIICs) in 346 RCC patients with long-term follow-up. PD-L1 positivity in tumor cells was associated with higher World Health Organization nucleolar grade (P<0.001), recurrence (P=0.011), and death due to RCC (P=0.031). PD-L1 positivity in TIICs was associated with higher nucleolar grade (P<0.001), higher T-stage (P=0.031), higher N-stage (P=0.01), recurrence (P=0.007), and death due to RCC (P=0.001). A significant positive association of time to cancer-specific death with both PD-L1-positive tumor cells and TIICs were also found. The data indicate that RCC patients with PD-L1-positive tumor cells and TIICs are at significant risk for cancer progression and the expression may be used as a complementary prognostic factor in the management of RCC patients.
2020
Carlsson J., Sundqvist P., Kosuta V., Falt A., Giunchi F., Fiorentino M., et al. (2020). PD-L1 Expression is Associated with Poor Prognosis in Renal Cell Carcinoma. APPLIED IMMUNOHISTOCHEMISTRY AND MOLECULAR MORPHOLOGY, 28(3), 213-220 [10.1097/PAI.0000000000000766].
Carlsson J.; Sundqvist P.; Kosuta V.; Falt A.; Giunchi F.; Fiorentino M.; Davidsson S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/693656
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