Addition of azobenzene-derivative 1 in its E configuration to an aqueous solution containing various guanosine borate esters induces a helical G-quartet based self-organization, stabilized by intercalation of the dye. The process is driven, in a domino fashion, by the initial host-guest interaction between the dye and a specific guanosine borate diester, whose structure can be thus assigned. This inclusion complex templates the formation of G-quartets. The quartets, in turn, pile up to form a supramolecular G-quadruplex structure, in which other G species present in solution are progressively included. The G-quadruplex can be reversibly broken and reformed by photoisomerization of the dye. This hierarchical and photosensitive self-assembly is unprecedented for simple guanosine derivatives.

Pieraccini S., Campitiello M., Carducci F., Davis J.T., Mariani P., Masiero S. (2019). Playing supramolecular dominoes with light: Building and breaking a photoreversible G-quadruplex made from guanosine, boric acid and an azobenzene. ORGANIC & BIOMOLECULAR CHEMISTRY, 17(10), 2759-2769 [10.1039/c9ob00193j].

Playing supramolecular dominoes with light: Building and breaking a photoreversible G-quadruplex made from guanosine, boric acid and an azobenzene

Pieraccini S.;CAMPITIELLO, MARILENA;Masiero S.
2019

Abstract

Addition of azobenzene-derivative 1 in its E configuration to an aqueous solution containing various guanosine borate esters induces a helical G-quartet based self-organization, stabilized by intercalation of the dye. The process is driven, in a domino fashion, by the initial host-guest interaction between the dye and a specific guanosine borate diester, whose structure can be thus assigned. This inclusion complex templates the formation of G-quartets. The quartets, in turn, pile up to form a supramolecular G-quadruplex structure, in which other G species present in solution are progressively included. The G-quadruplex can be reversibly broken and reformed by photoisomerization of the dye. This hierarchical and photosensitive self-assembly is unprecedented for simple guanosine derivatives.
2019
Pieraccini S., Campitiello M., Carducci F., Davis J.T., Mariani P., Masiero S. (2019). Playing supramolecular dominoes with light: Building and breaking a photoreversible G-quadruplex made from guanosine, boric acid and an azobenzene. ORGANIC & BIOMOLECULAR CHEMISTRY, 17(10), 2759-2769 [10.1039/c9ob00193j].
Pieraccini S.; Campitiello M.; Carducci F.; Davis J.T.; Mariani P.; Masiero S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/691222
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