The treatment of human leishmaniasis is currently based on few compounds that are highly toxic, expensive and have a high rate of treatment failure. A number of recent studies on new drugs focuses on natural or semi-synthetic compounds. Among them, the endoperoxide artemisinin, extracted from Artemisia annua, and some of its derivatives have shown leishmanicidal activity. In the present work, a series of structurally simple, fully synthetic 1,2-dioxanes were evaluated for in vitro antileishmanial activity against promastigotes of Leishmania donovani; the cytotoxicity for mammalian cells was also assessed. The six most promising compounds in terms of activity and selectivity were further investigated for their antileishmanial activity on the promastigote forms of L. tropica, L. major and L. infantum and against L. donovani amastigotes. The good performance in terms of potency and selectivity makes these six hits promising candidates for a preliminary lead optimization as antileishmanial agents.

Ortalli M., Varani S., Rosso C., Quintavalla A., Lombardo M., Trombini C. (2019). Evaluation of synthetic substituted 1,2-dioxanes as novel agents against human leishmaniasis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 170, 126-140 [10.1016/j.ejmech.2019.02.070].

Evaluation of synthetic substituted 1,2-dioxanes as novel agents against human leishmaniasis

Ortalli M.
Writing – Original Draft Preparation
;
Varani S.
Funding Acquisition
;
Rosso C.
Investigation
;
Quintavalla A.
Writing – Original Draft Preparation
;
Lombardo M.
Supervision
;
Trombini C.
Funding Acquisition
2019

Abstract

The treatment of human leishmaniasis is currently based on few compounds that are highly toxic, expensive and have a high rate of treatment failure. A number of recent studies on new drugs focuses on natural or semi-synthetic compounds. Among them, the endoperoxide artemisinin, extracted from Artemisia annua, and some of its derivatives have shown leishmanicidal activity. In the present work, a series of structurally simple, fully synthetic 1,2-dioxanes were evaluated for in vitro antileishmanial activity against promastigotes of Leishmania donovani; the cytotoxicity for mammalian cells was also assessed. The six most promising compounds in terms of activity and selectivity were further investigated for their antileishmanial activity on the promastigote forms of L. tropica, L. major and L. infantum and against L. donovani amastigotes. The good performance in terms of potency and selectivity makes these six hits promising candidates for a preliminary lead optimization as antileishmanial agents.
2019
Ortalli M., Varani S., Rosso C., Quintavalla A., Lombardo M., Trombini C. (2019). Evaluation of synthetic substituted 1,2-dioxanes as novel agents against human leishmaniasis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 170, 126-140 [10.1016/j.ejmech.2019.02.070].
Ortalli M.; Varani S.; Rosso C.; Quintavalla A.; Lombardo M.; Trombini C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/691213
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