Antimitochondrial antibodies (AMA) are the serologic cornerstone in the diagnosis of primary biliary cirrhosis (PBC), even if they are not detectable in a proportion of patients, notwithstanding the most sensitive and sophisticated technologies used. To fill in the serologic gap in AMA-negative PBC, there is sound evidence to consider antinuclear antibody (ANA) patterns, such as anti-multiple nuclear dots and anti-membranous/rim-like, as PBC-specific surrogate hallmarks of the disease, and their detection can be considered virtually diagnostic. Furthermore, particular ANA specificities, such as anti-gp210, anti-p62, anticentromere antibodies, and anti-dsDNA, may provide additional diagnostic and prognostic information.
Titolo: | Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis: diagnostic and prognostic value |
Autore/i: | MURATORI, LUIGI; GRANITO, ALESSANDRO; MURATORI, PAOLO; Pappas G; BIANCHI, FRANCESCO BIANCO |
Autore/i Unibo: | |
Anno: | 2008 |
Rivista: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.cld.2008.02.009 |
Abstract: | Antimitochondrial antibodies (AMA) are the serologic cornerstone in the diagnosis of primary biliary cirrhosis (PBC), even if they are not detectable in a proportion of patients, notwithstanding the most sensitive and sophisticated technologies used. To fill in the serologic gap in AMA-negative PBC, there is sound evidence to consider antinuclear antibody (ANA) patterns, such as anti-multiple nuclear dots and anti-membranous/rim-like, as PBC-specific surrogate hallmarks of the disease, and their detection can be considered virtually diagnostic. Furthermore, particular ANA specificities, such as anti-gp210, anti-p62, anticentromere antibodies, and anti-dsDNA, may provide additional diagnostic and prognostic information. |
Data prodotto definitivo in UGOV: | 2009-01-23 15:19:32 |
Appare nelle tipologie: | 1.01 Articolo in rivista |