Objective: To describe urban-rural differences in breast cancer incidence in Gharbiah, Egypt and to investigate if these differences could be explained by known risk factors of breast cancer. Methods: We used data from the population-based cancer registry of Gharbiah, Egypt to assess breast cancer incidence from 1999 through 2006. The Egyptian census provided data on district-specific population, age, and urban-rural classification. Incidence patterns of breast cancer by district and age-specific urban-rural differences were analyzed. Results: Overall, incidence rate of breast cancer was three to four times higher in urban areas than in rural areas (60.9/105-year for urban areas versus 17.8/105-year for rural areas; IRR=3.73, 95% CI=3.30, 4.22). Urban areas had consistently higher incidence of breast cancer across all age-groups for all years. Higher incidence of breast cancer was also seen in the more developed districts of Tanta and El-Mehalla. Conclusions: Higher incidence of breast cancer in urban and more developed populations might be related to higher exposure to xenoestrogens, as well as other endocrine disruptors and genotoxic substances. © 2010 Elsevier Ltd.
Urban-rural differences in breast cancer incidence in Egypt (1999-2006) / Dey, S.; Soliman, A.S.; Hablas, A.; Seifeldein, I.A.; Ismail, K.; Ramadan, M.; El-Hamzawy, H.; Wilson, M.L.; Banerjee, M.; Boffetta, P.; Harford, J.; Merajver, S.D.. - In: THE BREAST. - ISSN 0960-9776. - STAMPA. - 19:5(2010), pp. 417-423. [10.1016/j.breast.2010.04.005]
Urban-rural differences in breast cancer incidence in Egypt (1999-2006)
AL-ISMAIL, KHALID;RAMADAN, MOHAMED REFAT MOSTAFA;Boffetta, P.;
2010
Abstract
Objective: To describe urban-rural differences in breast cancer incidence in Gharbiah, Egypt and to investigate if these differences could be explained by known risk factors of breast cancer. Methods: We used data from the population-based cancer registry of Gharbiah, Egypt to assess breast cancer incidence from 1999 through 2006. The Egyptian census provided data on district-specific population, age, and urban-rural classification. Incidence patterns of breast cancer by district and age-specific urban-rural differences were analyzed. Results: Overall, incidence rate of breast cancer was three to four times higher in urban areas than in rural areas (60.9/105-year for urban areas versus 17.8/105-year for rural areas; IRR=3.73, 95% CI=3.30, 4.22). Urban areas had consistently higher incidence of breast cancer across all age-groups for all years. Higher incidence of breast cancer was also seen in the more developed districts of Tanta and El-Mehalla. Conclusions: Higher incidence of breast cancer in urban and more developed populations might be related to higher exposure to xenoestrogens, as well as other endocrine disruptors and genotoxic substances. © 2010 Elsevier Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.