Glutathione S-transferases (GSTs) are a family of enzymes that are known to play an important role in cellular protection against oxidative stress, including the oxidative stress caused by ultraviolet radiation. This study focused on the possible involvement of GSTM1 and GSTT1 polymorphisms in risk modulation of cutaneous melanoma. Within a case-control study, the presence of the null polymorphism at GSTM1 and GSTT1 was investigated in 188 cases of cutaneous melanoma and 152 controls. Information on socio-demographic characteristics, medical history, sun exposure and pigmentary characteristics were collected for all subjects. Logistic regression was used to estimate odds ratio (OR) and 95% confidence intervals (CI). An interaction was suggested between the GSTM1 and GSTT1 "null" genotype and episodes of sunburn in childhood OR of interaction (1.65, 95% CI (95% CI) 0.27-9.94). The risk of melanoma among the subset of participants who reported sunburns in childhood and who had both null variants, was nine (OR 9.16; 95% CI 1.18-70.9). The results suggest that subjects carrying both GSTM1 and GSTT1 null polymorphisms and experiencing sunburns in childhood have an extremely high risk of melanoma. © 2011 The Authors.

Polymorphisms of GSTM1 and GSTT1, sun exposure and the risk of melanoma: A case-control study / Fortes, C.; Mastroeni, S.; Boffetta, P.; Innocenzi, L.; Antonelli, G.; Giovi-Nazzo, R.; Anzidei, P.; Melchi, F.; D'atri, S.; Pasquini, P.; Venanzetti, F.. - In: ACTA DERMATO-VENEREOLOGICA. - ISSN 0001-5555. - STAMPA. - 91:3(2011), pp. 284-289. [10.2340/00015555-1078]

Polymorphisms of GSTM1 and GSTT1, sun exposure and the risk of melanoma: A case-control study

Boffetta, P.;
2011

Abstract

Glutathione S-transferases (GSTs) are a family of enzymes that are known to play an important role in cellular protection against oxidative stress, including the oxidative stress caused by ultraviolet radiation. This study focused on the possible involvement of GSTM1 and GSTT1 polymorphisms in risk modulation of cutaneous melanoma. Within a case-control study, the presence of the null polymorphism at GSTM1 and GSTT1 was investigated in 188 cases of cutaneous melanoma and 152 controls. Information on socio-demographic characteristics, medical history, sun exposure and pigmentary characteristics were collected for all subjects. Logistic regression was used to estimate odds ratio (OR) and 95% confidence intervals (CI). An interaction was suggested between the GSTM1 and GSTT1 "null" genotype and episodes of sunburn in childhood OR of interaction (1.65, 95% CI (95% CI) 0.27-9.94). The risk of melanoma among the subset of participants who reported sunburns in childhood and who had both null variants, was nine (OR 9.16; 95% CI 1.18-70.9). The results suggest that subjects carrying both GSTM1 and GSTT1 null polymorphisms and experiencing sunburns in childhood have an extremely high risk of melanoma. © 2011 The Authors.
2011
Polymorphisms of GSTM1 and GSTT1, sun exposure and the risk of melanoma: A case-control study / Fortes, C.; Mastroeni, S.; Boffetta, P.; Innocenzi, L.; Antonelli, G.; Giovi-Nazzo, R.; Anzidei, P.; Melchi, F.; D'atri, S.; Pasquini, P.; Venanzetti, F.. - In: ACTA DERMATO-VENEREOLOGICA. - ISSN 0001-5555. - STAMPA. - 91:3(2011), pp. 284-289. [10.2340/00015555-1078]
Fortes, C.; Mastroeni, S.; Boffetta, P.; Innocenzi, L.; Antonelli, G.; Giovi-Nazzo, R.; Anzidei, P.; Melchi, F.; D'atri, S.; Pasquini, P.; Venanzetti, F.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/682879
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 15
social impact