Lung cancer susceptibility locus at 5p15.33

Mckay, J. D.; Hung, R. J.; Gaborieau, V.; Boffetta, P.; Chabrier, A.; Byrnes, G.; Zaridze, D.; Mukeria, A.; Szeszenia-Dabrowska, N.; Lissowska, J.; Rudnai, P.; Fabianova, E.; Mates, D.; Bencko, V.; Foretova, L.; Janout, V.; Mclaughlin, J.; Shepherd, F.; Montpetit, A.; Narod, S.; Krokan, H. E.; Skorpen, F.; Elvestad, M. B.; Vatten, L.; Njølstad, I.; Axelsson, T.; Chen, C.; Goodman, G.; Barnett, M.; Loomis, M. M.; Lubiski, J.; Matyjasik, J.; Lener, M.; Oszutowska, D.; Field, J.; Liloglou, T.; Xinarianos, G.; Cassidy, A.; Zelenika, D.; Boland, A.; Delepine, M.; Foglio, M.; Lechner, D.; Matsuda, F.; Blanche, H.; Gut, I.; Heath, S.; Lathrop, M.; Brennan, P.; Vineis, P.; Clavel-Chapelon, F.; Palli, D.; Tumino, R.; Krogh, V.; Panico, S.; González, C. A.; Ramón Quirós, J.; Martínez, C.; Navarro, C.; Ardanaz, E.; Larrãaga, N.; Kham, K. T.; Key, T.; Bueno-De-Mesquita, H. B.; Peeters, P. H. M.; Trichopoulou, A.; Linseisen, J.; Boeing, H.; Hallmans, G.; Overvad, K.; Tjønneland, A.; Kumle, M.; Riboli, E.

doi:10.1038/ng.254

We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 × 10-7 and P = 4 × 10-6) and replicated by the independent study series (P = 7 × 10-5 and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology. © 2008 Nature Publishing Group.

McKay, J.D., Hung, R.J., Gaborieau, V., Boffetta, P., Chabrier, A., Byrnes, G., et al. (2008). Lung cancer susceptibility locus at 5p15.33. NATURE GENETICS, 40(12), 1404-1406 [10.1038/ng.254].

Lung cancer susceptibility locus at 5p15.33

McKay, J. D.;Hung, R. J.;Gaborieau, V.;Boffetta, P.;Chabrier, A.;Byrnes, G.;Zaridze, D.;Mukeria, A.;Szeszenia-Dabrowska, N.;Lissowska, J.;Rudnai, P.;Fabianova, E.;Mates, D.;Bencko, V.;Foretova, L.;Janout, V.;McLaughlin, J.;Shepherd, F.;Montpetit, A.;Narod, S.;Krokan, H. E.;Skorpen, F.;Elvestad, M. B.;Vatten, L.;Njølstad, I.;Axelsson, T.;Chen, C.;Goodman, G.;Barnett, M.;Loomis, M. M.;Lubiski, J.;Matyjasik, J.;Lener, M.;Oszutowska, D.;Field, J.;Liloglou, T.;Xinarianos, G.;Cassidy, A.;Zelenika, D.;Boland, A.;Delepine, M.;Foglio, M.;Lechner, D.;Matsuda, F.;Blanche, H.;Gut, I.;Heath, S.;Lathrop, M.;Brennan, P.;Vineis, P.;Clavel-Chapelon, F.;Palli, D.;Tumino, R.;Krogh, V.;Panico, S.;González, C. A.;Ramón Quirós, J.;Martínez, C.;Navarro, C.;Ardanaz, E.;Larrãaga, N.;Kham, K. T.;Key, T.;Bueno-De-Mesquita, H. B.;Peeters, P. H. M.;Trichopoulou, A.;Linseisen, J.;Boeing, H.;Hallmans, G.;Overvad, K.;Tjønneland, A.;Kumle, M.;Riboli, E.

2008

Abstract

We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 × 10-7 and P = 4 × 10-6) and replicated by the independent study series (P = 7 × 10-5 and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology. © 2008 Nature Publishing Group.

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				2008
			
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				NATURE GENETICS
			
	Codice DOI
	
				https://dx.doi.org/10.1038/ng.254
			
	Citazione
	
				McKay, J.D., Hung, R.J., Gaborieau, V., Boffetta, P., Chabrier, A., Byrnes, G., et al. (2008). Lung cancer susceptibility locus at 5p15.33. NATURE GENETICS, 40(12), 1404-1406 [10.1038/ng.254].
			
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						McKay, J.D.; Hung, R.J.; Gaborieau, V.; Boffetta, P.; Chabrier, A.; Byrnes, G.; Zaridze, D.; Mukeria, A.; Szeszenia-Dabrowska, N.; Lissowska, J.; Rudn...espandi
						
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/682678

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