Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

Conde, L.; Halperin, E.; Akers, N. K.; Brown, K. M.; Smedby, K. E.; Rothman, N.; Nieters, A.; Slager, S. L.; Brooks-Wilson, A.; Agana, L.; Riby, J.; Liu, Jingyi; Adami, H. -O.; Darabi, H.; Hjalgrim, H.; Low, H. -Q.; Humphreys, K.; Melbye, M.; Chang, E. T.; Glimelius, B.; Cozen, W.; Davis, S.; Hartge, P.; Morton, L. M.; Schenk, M.; Wang, S. S.; Armstrong, B.; Kricker, A.; Milliken, S.; Purdue, M. P.; Vajdic, C. M.; Boyle, P.; Lan, Q.; Zahm, S. H.; Zhang, Y.; Zheng, T.; Becker, N.; Benavente, Y.; Boffetta, P.; Brennan, P.; Butterbach, K.; Cocco, P.; Foretova, L.; Maynadié, M.; De Sanjosé, S.; Staines, A.; Spinelli, J. J.; Achenbach, S. J.; Call, T. G.; Camp, N. J.; Glenn, M.; Caporaso, N. E.; Cerhan, J. R.; Cunningham, J. M.; Goldin, L. R.; Hanson, C. A.; Kay, N. E.; Lanasa, M. C.; Leis, J. F.; Marti, G. E.; Rabe, K. G.; Rassenti, L. Z.; Spector, L. G.; Strom, S. S.; Vachon, C. M.; Weinberg, J. B.; Holly, E. A.; Chanock, S.; Smith, M. T.; Bracci, P. M.; Skibola, C. F.

doi:10.1038/ng.626

To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10-29 and rs7755224, combined P = 2.00 × 10-19; r2 = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10-9). © 2010 Nature America, Inc. All rights reserved.

Conde, L., Halperin, E., Akers, N., Brown, K., Smedby, K., Rothman, N., et al. (2010). Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. NATURE GENETICS, 42(8), 661-664 [10.1038/ng.626].