Versatile exposure system for laboratory experiments finalized to therapeutic applications in the if range

Several nanotechnologies rely on the use of magnetic field for therapeutic purposes, as cancer treatment, inflammation, and diseases of the nervous system. The liposomal drug delivery system is a novel technique that allows a controlled release of drugs encapsulated in a nano-carrier (i.e. liposomes), by the application of an external (electric, magnetic, thermal) stimulus to guarantee a local effect on the region where the disease has developed. Another interesting application of magnetic field is the transcranial magnetic stimulation, which is used to the study and treatment of a wide variety of neurologic and psychiatric conditions. In this paper, an analytical analysis and a numeric modelling approach is reported for the design of a versatile magnetic exposure system, suitable for different applications: in vitro magnetoliposomes (vesicles containing super-paramagnetic iron oxide nanoparticles) drug delivery, and in vitro studies to understand the action of magnetic stimulation on neurons. The simulation shows that the system is able to generate intensities of the order of mT, in a frequency range up to 20 kHz, without causing secondary effects such as a local thermal increase.