The addition of small quantities of water to the proline or prolinamide catalysed aldol addition of acetone to isatin can result in increased enantioselectivity. DFT B3LYP calculations with a water molecule explicitly incorporated in the aldol transition states reproduces the observed enantioselectivity.
G. Angelici, R. J. Corrêa, S. J. Garden, C. Tomasini (2009). Water influences the enantioselectivity in the proline or prolinamide-catalyzed aldol addition of acetone to isatins. TETRAHEDRON LETTERS, 50, 814-817 [10.1016/j.tetlet.2008.12.007].
Water influences the enantioselectivity in the proline or prolinamide-catalyzed aldol addition of acetone to isatins
ANGELICI, GAETANO;TOMASINI, CLAUDIA
2009
Abstract
The addition of small quantities of water to the proline or prolinamide catalysed aldol addition of acetone to isatin can result in increased enantioselectivity. DFT B3LYP calculations with a water molecule explicitly incorporated in the aldol transition states reproduces the observed enantioselectivity.File in questo prodotto:
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