The identification of key oncogenic driver alterations in NSCLC has led to the development of tailored treatments. ROS1 rearrangements occur in 1% to 2% of NSCLC.1 Dysregulation of MNNG HOS Transforming gene (MET) signaling through MET exon 14 skipping mutations or MET amplification has been reported in 3% to 4% and 2% to 5% of adenocarcinomas, respectively.2 To our knowledge, co-alteration of c-MET and ROS1 or ALK tyrosine kinase receptor gene (ALK) have not been described yet and the optimal management of this clinical condition is unknown.

Co-alteration of c-Met and ROS1 in Advanced NSCLC: ROS1 Wins

Rihawi K;Fiorentino M;SALVAGNI, SANDRO;Brocchi S;Ardizzoni A
2018

Abstract

The identification of key oncogenic driver alterations in NSCLC has led to the development of tailored treatments. ROS1 rearrangements occur in 1% to 2% of NSCLC.1 Dysregulation of MNNG HOS Transforming gene (MET) signaling through MET exon 14 skipping mutations or MET amplification has been reported in 3% to 4% and 2% to 5% of adenocarcinomas, respectively.2 To our knowledge, co-alteration of c-MET and ROS1 or ALK tyrosine kinase receptor gene (ALK) have not been described yet and the optimal management of this clinical condition is unknown.
Rihawi K, Cinausero M, Fiorentino M, Salvagni S, Brocchi S, Ardizzoni A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/678771
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