Aim of this work is the modeling the parenchymal and vascular/stromal morphology of human glands, from their scintigraphic or echographic images; the model of interest, here, is the adult human thyroid [R. Toni et al, "Ex-situ bioengineering of bioartificial endocrine glands: a new frontier in regenerative medicine of soft tissue organs", Annals of Anatomy 193:381-394, 2011]. Simulation of the thyroid morphology is approached, here, via a hybrid technique, involving a numerical reconstruction of surfaces through edge-detection and data fitting, followed by a fractal modeling of the vascular/stromal skeleton (SSV), constrained by anatomical morphometric data information. A software is developed in Mathematica, constituted of a computational kernel of mathematical and visualization routines. The output of this software is exported in stereo-lithographic format, suitable for rapid prototyping. This work, funded by Grant PRIN 2008, stems from a cooperation of many researchers: M. Sofroniou, A. Gatto and the Research Units at Modena and Bologna Universities, R. Toni and the Research Units at Parma University and Hospital, Bologna CNR and IOR and Faenza CNR.
Glandular Morphology Biomodeling
Spaletta Giulia;
2013
Abstract
Aim of this work is the modeling the parenchymal and vascular/stromal morphology of human glands, from their scintigraphic or echographic images; the model of interest, here, is the adult human thyroid [R. Toni et al, "Ex-situ bioengineering of bioartificial endocrine glands: a new frontier in regenerative medicine of soft tissue organs", Annals of Anatomy 193:381-394, 2011]. Simulation of the thyroid morphology is approached, here, via a hybrid technique, involving a numerical reconstruction of surfaces through edge-detection and data fitting, followed by a fractal modeling of the vascular/stromal skeleton (SSV), constrained by anatomical morphometric data information. A software is developed in Mathematica, constituted of a computational kernel of mathematical and visualization routines. The output of this software is exported in stereo-lithographic format, suitable for rapid prototyping. This work, funded by Grant PRIN 2008, stems from a cooperation of many researchers: M. Sofroniou, A. Gatto and the Research Units at Modena and Bologna Universities, R. Toni and the Research Units at Parma University and Hospital, Bologna CNR and IOR and Faenza CNR.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
