Background: Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent. Methods: We pooled 10 case-control studies within the Pancreatic Cancer Case-control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models. Results: The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98-1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15-2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82-20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors. Conclusions: This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance. © The Author 2013. Published by Oxford University Press on behalf of the European Society for Medical Oncology All rights reserved.
Ulcer, gastric surgery and pancreatic cancer risk: An analysis from the international pancreatic cancer case-control consortium (PanC4) / Bosetti, C.; Lucenteforte, E.; Bracci, P.M.; Negri, E.; Neale, R.E.; Risch, H.A.; Olson, S.H.; Gallinger, S.; Miller, A.B.; Bueno-de-Mesquita, H.B.; Talamini, R.; Polesel, J.; Ghadirian, P.; Baghurst, P.A.; Zatonski, W.; Fontham, E.; Holly, E.A.; Gao, Y.T.; Yu, H.; Kurtz, R.C.; Cotterchio, M.; Maisonneuve, P.; Zeegers, M.P.; Duell, E.J.; Boffetta, P.; La Vecchia, C.. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - ELETTRONICO. - 24:11(2013), pp. 2903-2910. [10.1093/annonc/mdt336]
Ulcer, gastric surgery and pancreatic cancer risk: An analysis from the international pancreatic cancer case-control consortium (PanC4)
Negri, E.;Boffetta, P.;
2013
Abstract
Background: Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent. Methods: We pooled 10 case-control studies within the Pancreatic Cancer Case-control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models. Results: The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98-1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15-2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82-20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors. Conclusions: This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance. © The Author 2013. Published by Oxford University Press on behalf of the European Society for Medical Oncology All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
