To quantify the magnitude of the association between alcohol and oral and pharyngeal cancer (OPC) by sex,smoking habits, type of alcoholic beverage and other factors. Methods: We combined findings from all case-control and cohort studies published until September 2010 and present in this article the results classified by these factors, using a meta- nalytic approach.Summary relative risks (RRs) were obtained using random-effects models; heterogeneity was assessed using the X2 test. Results: The association between alcohol and OPC risk was similar in men and women, with similar dose-response relationships.No notable differences were found with respect to geographic area and other factors, both for drinking overall and heavy (=4 drinks/day) drinking. Among never/non-current smokers, the pooled RRs were 1.32 (95% confidence interval, CI, 1.05-1.67) for drinking,and 2.54 (95% CI, 1.80-3.58) for heavy drinking. The corresponding RRs in smokers were 2.92 (95% CI, 2.31-3.70) and 6.32(95% CI, 5.05-7.90). The pooled RRs for any drinking irrespective of smoking were 2.12 (95% CI, 1.37-3.29) for wine-, 2.43 (95%CI, 1.92-3.07) for beer- and 2.30 (95% CI, 1.78-2.98) for spirits-only drinking. The corresponding RRs for heavy drinking were 4.92 (95% CI, 2.80-8.65), 4.20 (95% CI, 1.43-12.38) and 5.20 (95% CI, 2.77-9.78). Conclusion: The alcohol-related RRs are similar with respect to sex, geographic area and type of alcoholic beverage. The association between alcohol and OPC is stronger in smokers than in non-smokers. © The Author 2012. Medical Council on Alcohol and Oxford University Press. All rights reserved.
Turati, F., Garavello, W., Tramacere, I., Pelucchi, C., Galeone, C., Bagnardi, V., et al. (2013). A meta-analysis of alcohol drinking and oral and pharyngeal cancers: Results from subgroup analyses. ALCOHOL AND ALCOHOLISM, 48(1), 107-118 [10.1093/alcalc/ags100].
A meta-analysis of alcohol drinking and oral and pharyngeal cancers: Results from subgroup analyses
Boffetta, P.;Negri, E.
2013
Abstract
To quantify the magnitude of the association between alcohol and oral and pharyngeal cancer (OPC) by sex,smoking habits, type of alcoholic beverage and other factors. Methods: We combined findings from all case-control and cohort studies published until September 2010 and present in this article the results classified by these factors, using a meta- nalytic approach.Summary relative risks (RRs) were obtained using random-effects models; heterogeneity was assessed using the X2 test. Results: The association between alcohol and OPC risk was similar in men and women, with similar dose-response relationships.No notable differences were found with respect to geographic area and other factors, both for drinking overall and heavy (=4 drinks/day) drinking. Among never/non-current smokers, the pooled RRs were 1.32 (95% confidence interval, CI, 1.05-1.67) for drinking,and 2.54 (95% CI, 1.80-3.58) for heavy drinking. The corresponding RRs in smokers were 2.92 (95% CI, 2.31-3.70) and 6.32(95% CI, 5.05-7.90). The pooled RRs for any drinking irrespective of smoking were 2.12 (95% CI, 1.37-3.29) for wine-, 2.43 (95%CI, 1.92-3.07) for beer- and 2.30 (95% CI, 1.78-2.98) for spirits-only drinking. The corresponding RRs for heavy drinking were 4.92 (95% CI, 2.80-8.65), 4.20 (95% CI, 1.43-12.38) and 5.20 (95% CI, 2.77-9.78). Conclusion: The alcohol-related RRs are similar with respect to sex, geographic area and type of alcoholic beverage. The association between alcohol and OPC is stronger in smokers than in non-smokers. © The Author 2012. Medical Council on Alcohol and Oxford University Press. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
