Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10 '15) and HLA-B (rs2922994, P=2.43 × 10 '9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility. © 2015 Macmillan Publishers Limited. All rights reserved.

Vijai, J., Wang, Z., Berndt, S., Skibola, C., Slager, S., De Sanjose, S., et al. (2015). A genome-wide association study of marginal zone lymphoma shows association to the HLA region. NATURE COMMUNICATIONS, 6, 5751-5751 [10.1038/ncomms6751].

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Boffetta, P.;
2015

Abstract

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10 '15) and HLA-B (rs2922994, P=2.43 × 10 '9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility. © 2015 Macmillan Publishers Limited. All rights reserved.
2015
Vijai, J., Wang, Z., Berndt, S., Skibola, C., Slager, S., De Sanjose, S., et al. (2015). A genome-wide association study of marginal zone lymphoma shows association to the HLA region. NATURE COMMUNICATIONS, 6, 5751-5751 [10.1038/ncomms6751].
Vijai, J.; Wang, Z.; Berndt, S.I.; Skibola, C.F.; Slager, S.L.; De Sanjose, S.; Melbye, M.; Glimelius, B.; Bracci, P.M.; Conde, L.; Birmann, B.M.; Wan...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/671467
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