Extramedullary involvement of B-cell Acute Lymphoblastic Leukemia (EM-ALL) is a rare occurrence, characterized by dismal outcome and the absence of a defined and shared therapeutic approach. In the landscape of innovative compounds, inotuzumab ozogamicin (IO) is a promising drug, whose mechanism of action relies on the killing of CD22 positive leukemic cells, through the delivery, after cell binding, of a molecule of calicheamicin.
Inotuzumab ozogamicin is effective in relapsed/refractory extramedullary B acute lymphoblastic leukemia
Bertamini, Luca;Nanni, Jacopo;Marconi, Giovanni;Abbenante, Mariachiara;Robustelli, Valentina;Matti, Antonella;Paolini, Stefania;Sartor, Chiara;Monaco, Silvia Lo;Fontana, Maria Chiara;Cavo, Michele;Curti, Antonio;Martinelli, Giovanni;Papayannidis, Cristina
2018
Abstract
Extramedullary involvement of B-cell Acute Lymphoblastic Leukemia (EM-ALL) is a rare occurrence, characterized by dismal outcome and the absence of a defined and shared therapeutic approach. In the landscape of innovative compounds, inotuzumab ozogamicin (IO) is a promising drug, whose mechanism of action relies on the killing of CD22 positive leukemic cells, through the delivery, after cell binding, of a molecule of calicheamicin.File in questo prodotto:
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