OBJECTIVES: Hemorrhagic shock followed by resuscitation (HSR) commonly triggers an inflammatory response that leads to acute respiratory distress syndrome. Hypothesis: HSR exacerbates mechanical stress-induced lung injury by rendering the lung more susceptible to ventilator-induced lung injury. METHODS: Rats were subjected to HSR, and were randomized into an HSR + high tidal volume and zero positive end-expiratory pressure (PEEP) or a HSR + low tidal volume with 5 cm H(2)O PEEP. A sham-operated rat + high tidal volume and zero PEEP served as a control. RESULTS: HSR increased susceptibility to ventilator-induced lung injury as evidenced by an increase in lung elastance and the wet/dry ratio and a reduction in Pa(O(2)) as compared with the other groups. The lung injury observed in the HSR + high tidal volume group was associated with a higher level of interleukin 6 in the lung and blood, increased epithelial cell apoptosis in the kidney and small intestine villi, and a tendency toward high levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatinine in plasma. CONCLUSIONS: HSR priming renders the lung and kidney more susceptible to mechanical ventilation-induced organ injury.

Crimi E, Zhang H, Han RN, Del Sorbo L, Ranieri VM, Slutsky AS (2006). Ischemia and reperfusion increases susceptibility to ventilator-induced lung injury in rats. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 174(2), 178-186 [10.1164/rccm.200507-1178OC].

Ischemia and reperfusion increases susceptibility to ventilator-induced lung injury in rats

Ranieri VM;
2006

Abstract

OBJECTIVES: Hemorrhagic shock followed by resuscitation (HSR) commonly triggers an inflammatory response that leads to acute respiratory distress syndrome. Hypothesis: HSR exacerbates mechanical stress-induced lung injury by rendering the lung more susceptible to ventilator-induced lung injury. METHODS: Rats were subjected to HSR, and were randomized into an HSR + high tidal volume and zero positive end-expiratory pressure (PEEP) or a HSR + low tidal volume with 5 cm H(2)O PEEP. A sham-operated rat + high tidal volume and zero PEEP served as a control. RESULTS: HSR increased susceptibility to ventilator-induced lung injury as evidenced by an increase in lung elastance and the wet/dry ratio and a reduction in Pa(O(2)) as compared with the other groups. The lung injury observed in the HSR + high tidal volume group was associated with a higher level of interleukin 6 in the lung and blood, increased epithelial cell apoptosis in the kidney and small intestine villi, and a tendency toward high levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatinine in plasma. CONCLUSIONS: HSR priming renders the lung and kidney more susceptible to mechanical ventilation-induced organ injury.
2006
Crimi E, Zhang H, Han RN, Del Sorbo L, Ranieri VM, Slutsky AS (2006). Ischemia and reperfusion increases susceptibility to ventilator-induced lung injury in rats. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 174(2), 178-186 [10.1164/rccm.200507-1178OC].
Crimi E; Zhang H; Han RN; Del Sorbo L; Ranieri VM; Slutsky AS
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/670505
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