Objective: To examine whether adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, is associated with longer life expectancy among elderly Europeans. Design: Multicentre, prospective cohort study. Setting: Nine European countries (Denmark, France, Germany, Greece, Italy, the Netherlands, Spain, Sweden, United Kingdom). Participants: 74 607 men and women, aged 60 or more, without coronary heart disease, stroke, or cancer at enrolment and with complete information about dietary intake and potentially confounding variables. Main outcome measures: Extent of adherence to a modified Mediterranean diet using a scoring system on a 10 point scale, and death from any cause by time of occurrence, modelled through Cox regression. Results: An increase in the modified Mediterranean diet score was associated with lower overall mortality, a two unit increment corresponding to a statistically significant reduction of 8% (95% confidence interval 3% to 12%). No statistically significant evidence of heterogeneity was found among countries in the association of the score with overall mortality even though the association was stronger in Greece and Spain. When dietary exposures were calibrated across countries, the reduction in mortality was 7% (1% to 12%). Conclusion: The Mediterranean diet, modified so as to apply across Europe, was associated with increased survival among older people.
Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study / Trichopoulou, A. and Orfanos, P. and Norat, T. and Bueno-de-Mesquita, B. and Ocké, M.C. and Peeters, P.H.M. and van der Schouw, Y.T. and Boeing, H. and Hoffmann, K. and Boffetta, P. and Nagel, G. and Masala, G. and Krogh, V. and Panico, S. and Tumino, R. and Vineis, P. and Bamia, C. and Naska, A. and Benetou, V. and Ferrari, P. and Slimani, N. and Pera, G. and Martinez-Garcia, C. and Navarro, C. and Rodriguez-Barranco, M. and Dorronsoro, M. and Spencer, E.A. and Key, T.J. and Bingham, S. and Khaw, K.-T. and Kesse, E. and Clavel-Chapelon, F. and Boutron-Ruault, M.-C. and Berglund, G. and Wirfalt, E. and Hallmans, G. and Johansson, I. and Tjonneland, A. and Olsen, A. and Overvad, K. and Hundborg, H.H. and Riboli, E. and Trichopoulos, D.. - In: BMJ. BRITISH MEDICAL JOURNAL. - ISSN 0959-8146. - STAMPA. - 330:7498(2005), pp. 991-995. [10.1136/bmj.38415.644155.8F]
Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study
Boffetta, P.;
2005
Abstract
Objective: To examine whether adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, is associated with longer life expectancy among elderly Europeans. Design: Multicentre, prospective cohort study. Setting: Nine European countries (Denmark, France, Germany, Greece, Italy, the Netherlands, Spain, Sweden, United Kingdom). Participants: 74 607 men and women, aged 60 or more, without coronary heart disease, stroke, or cancer at enrolment and with complete information about dietary intake and potentially confounding variables. Main outcome measures: Extent of adherence to a modified Mediterranean diet using a scoring system on a 10 point scale, and death from any cause by time of occurrence, modelled through Cox regression. Results: An increase in the modified Mediterranean diet score was associated with lower overall mortality, a two unit increment corresponding to a statistically significant reduction of 8% (95% confidence interval 3% to 12%). No statistically significant evidence of heterogeneity was found among countries in the association of the score with overall mortality even though the association was stronger in Greece and Spain. When dietary exposures were calibrated across countries, the reduction in mortality was 7% (1% to 12%). Conclusion: The Mediterranean diet, modified so as to apply across Europe, was associated with increased survival among older people.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
