Adenosarcomas are the rarest form of uterine sarcomas, and clinical experience with their management is still limited. Here, we reported 7 patients with uterine adenosarcoma referred to our institution, focusing on main pathologic features, their medical history, and long-term follow-up. Among these patients, we provided a detailed description of the medical history of a 49-year-old woman with advanced uterine adenosarcoma with sarcomatous overgrowth who presented a brilliant radiologic and pathologic response after 3 cycles of epirubicin and ifosfamide, ultimately achieving an extraordinary long-term outcome through an integrated surgical and medical approach. Our single-centre experience would suggest that aggressive uterine adenosarcomas with sarcomatous overgrowth are sensitive to standard epirubicin and ifosfamide and that an integrated approach, both medical and surgical, could be considered in clinical practice, again emphasizing the relevant role of multidisciplinary management for this extremely rare disease.

Nannini, M., Dondi, G., Santini, D., De Leo, A., Dei Tos, A.P., Zamagni, C., et al. (2018). A Single-Centre Experience on the Management of Adenosarcoma: A Successful Report of an Integrated Medical and Surgical Approach. CLINICAL MEDICINE INSIGHTS: ONCOLOGY, 12, 1-9 [10.1177/1179554918782477].

A Single-Centre Experience on the Management of Adenosarcoma: A Successful Report of an Integrated Medical and Surgical Approach

Nannini, Margherita
;
Dondi, Giulia;De Leo, Antonio;Zamagni, Claudio;Saponara, Maristella;Gatto, Lidia;Nigro, Concetta;Zompatori, Maurizio;De Iaco, Pierandrea;Perrone, Anna Myriam;Pantaleo, Maria Abbondanza
2018

Abstract

Adenosarcomas are the rarest form of uterine sarcomas, and clinical experience with their management is still limited. Here, we reported 7 patients with uterine adenosarcoma referred to our institution, focusing on main pathologic features, their medical history, and long-term follow-up. Among these patients, we provided a detailed description of the medical history of a 49-year-old woman with advanced uterine adenosarcoma with sarcomatous overgrowth who presented a brilliant radiologic and pathologic response after 3 cycles of epirubicin and ifosfamide, ultimately achieving an extraordinary long-term outcome through an integrated surgical and medical approach. Our single-centre experience would suggest that aggressive uterine adenosarcomas with sarcomatous overgrowth are sensitive to standard epirubicin and ifosfamide and that an integrated approach, both medical and surgical, could be considered in clinical practice, again emphasizing the relevant role of multidisciplinary management for this extremely rare disease.
2018
Nannini, M., Dondi, G., Santini, D., De Leo, A., Dei Tos, A.P., Zamagni, C., et al. (2018). A Single-Centre Experience on the Management of Adenosarcoma: A Successful Report of an Integrated Medical and Surgical Approach. CLINICAL MEDICINE INSIGHTS: ONCOLOGY, 12, 1-9 [10.1177/1179554918782477].
Nannini, Margherita*; Dondi, Giulia; Santini, Donatella; De Leo, Antonio; Dei Tos, Angelo Paolo; Zamagni, Claudio; Saponara, Maristella; Gatto, Lidia;...espandi
File in questo prodotto:
File Dimensione Formato  
A Single-Centre Experience on the Management of Adenosarcoma.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale (CCBYNC)
Dimensione 705.47 kB
Formato Adobe PDF
705.47 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/663389
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 7
social impact