The first peri‐ and stereoselective [10+4] cycloaddition between catalytically generated amino isobenzofulvenes and electron‐deficient dienes is described. The highly stereoselective catalytic [10+4] cycloaddition exhibits a broad scope with high yields, reflecting a robust higher‐order cycloaddition. Experimental and computational investigations support a kinetic distribution of intermediate rotamers dictating the enantioselectivity, which relies heavily on additive effects.

Catalytic Enantioselective [10+4] Cycloadditions

Giulio Bertuzzi;
2018

Abstract

The first peri‐ and stereoselective [10+4] cycloaddition between catalytically generated amino isobenzofulvenes and electron‐deficient dienes is described. The highly stereoselective catalytic [10+4] cycloaddition exhibits a broad scope with high yields, reflecting a robust higher‐order cycloaddition. Experimental and computational investigations support a kinetic distribution of intermediate rotamers dictating the enantioselectivity, which relies heavily on additive effects.
Bjarke S. Donslund; Nicolaj Innunquag Jessen; Giulio Bertuzzi; Maxime Giardinetti; Teresa A. Palazzo; Mette Louise Christensen; Karl Anker Jørgensen
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/663193
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