Chiral resolution of racemic etiracetam was achieved via co-crystallization with ZnCl2. Depending on the amount of ZnCl2 either a stable racemic compound or a stable conglomerate can be obtained. Excess ZnCl2 triggers the quantitative conversion of the racemate into the conglomerate solid; this unprecedented behaviour was investigated through a racetam/ZnCl2/solvent phase diagram.
Solid-state chiral resolution mediated by stoichiometry: Crystallizing etiracetam with ZnCl2 / Shemchuk, Oleksii; Song, Lixing; Robeyns, Koen; Braga, Dario; Grepioni, Fabrizia*; Leyssens, Tom. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 54:77(2018), pp. 10890-10892. [10.1039/c8cc06199h]
Solid-state chiral resolution mediated by stoichiometry: Crystallizing etiracetam with ZnCl2
Shemchuk, Oleksii;Braga, Dario;Grepioni, Fabrizia
;
2018
Abstract
Chiral resolution of racemic etiracetam was achieved via co-crystallization with ZnCl2. Depending on the amount of ZnCl2 either a stable racemic compound or a stable conglomerate can be obtained. Excess ZnCl2 triggers the quantitative conversion of the racemate into the conglomerate solid; this unprecedented behaviour was investigated through a racetam/ZnCl2/solvent phase diagram.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
