Chiral resolution of racemic etiracetam was achieved via co-crystallization with ZnCl2. Depending on the amount of ZnCl2 either a stable racemic compound or a stable conglomerate can be obtained. Excess ZnCl2 triggers the quantitative conversion of the racemate into the conglomerate solid; this unprecedented behaviour was investigated through a racetam/ZnCl2/solvent phase diagram.
Shemchuk, O., Song, L., Robeyns, K., Braga, D., Grepioni, F., Leyssens, T. (2018). Solid-state chiral resolution mediated by stoichiometry: Crystallizing etiracetam with ZnCl2. CHEMICAL COMMUNICATIONS, 54(77), 10890-10892 [10.1039/c8cc06199h].
Solid-state chiral resolution mediated by stoichiometry: Crystallizing etiracetam with ZnCl2
Shemchuk, Oleksii;Braga, Dario;Grepioni, Fabrizia
;
2018
Abstract
Chiral resolution of racemic etiracetam was achieved via co-crystallization with ZnCl2. Depending on the amount of ZnCl2 either a stable racemic compound or a stable conglomerate can be obtained. Excess ZnCl2 triggers the quantitative conversion of the racemate into the conglomerate solid; this unprecedented behaviour was investigated through a racetam/ZnCl2/solvent phase diagram.File in questo prodotto:
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