background Primary prevention represents the best treatment for cardiovascular(CV) diseases.Especially among younger patients non-pharmacologic approaches are frequently underused.We started aproject of in-hospital physical activity program for primary prevention among high-risk patients.Aims To evaluate metabolic and vascular derangement among conside-red-healthy overweight subjects before a 3 months-course of in-hospital physical activity.Methods 70 consecutive obese patients with no history of acute vascu-lar events(IMA,stroke/TIA or peripheral artery disease)or other diagno-sed comorbidities were enrolled.Each patient underwent to completemetabolic/cardiovascular evaluation before physical activity.results Baseline characteristics were a mean age of 56.8±8.91 years(M:F 2:1,7),BMI of 34.2±5.69g/m2.CV familiarity was present in 45%,hypertension in 64.3%,smoke in 16.7%.We observed high prevalence of insulin resistance(HOMA Index 7.21±6.44) and hypertriglyceridemia;preclinicalmarkers showed endothelial dysfunction (FMD 7.43±10.4%) and high prevalence of increased IMT(30% of the sample);echocardiography showedan increased left ventricle mass(MVSI 108.2±34.0g/m2);double product at stress testresul-ted within lower limits (25.857±6.023).Framingham risk was 14.8%,with a 13.8% comparative increase.conclusions In this sample of italian obese patients we observed a high prevalence of endothelial dysfunction,insulin-resistance,hypertension with end-organ damage with an increased risk for CAD.Paradoxically,we should apply an aggressive therapy for these “healthy”,high-risk,subjects

Metabolic and vascular alterations in “healthy” overweight subjects

L. Falsetti
Writing – Original Draft Preparation
;
2012

Abstract

background Primary prevention represents the best treatment for cardiovascular(CV) diseases.Especially among younger patients non-pharmacologic approaches are frequently underused.We started aproject of in-hospital physical activity program for primary prevention among high-risk patients.Aims To evaluate metabolic and vascular derangement among conside-red-healthy overweight subjects before a 3 months-course of in-hospital physical activity.Methods 70 consecutive obese patients with no history of acute vascu-lar events(IMA,stroke/TIA or peripheral artery disease)or other diagno-sed comorbidities were enrolled.Each patient underwent to completemetabolic/cardiovascular evaluation before physical activity.results Baseline characteristics were a mean age of 56.8±8.91 years(M:F 2:1,7),BMI of 34.2±5.69g/m2.CV familiarity was present in 45%,hypertension in 64.3%,smoke in 16.7%.We observed high prevalence of insulin resistance(HOMA Index 7.21±6.44) and hypertriglyceridemia;preclinicalmarkers showed endothelial dysfunction (FMD 7.43±10.4%) and high prevalence of increased IMT(30% of the sample);echocardiography showedan increased left ventricle mass(MVSI 108.2±34.0g/m2);double product at stress testresul-ted within lower limits (25.857±6.023).Framingham risk was 14.8%,with a 13.8% comparative increase.conclusions In this sample of italian obese patients we observed a high prevalence of endothelial dysfunction,insulin-resistance,hypertension with end-organ damage with an increased risk for CAD.Paradoxically,we should apply an aggressive therapy for these “healthy”,high-risk,subjects
2012
Vol 6, No 1s (2012) • XVII Congresso Nazionale FADOI 5-8 maggio 2012, Rimini
56
57
L. Falsetti, N. Tarquinio, W. Capeci, A. Balloni, A. Gentile, V. Catozzo, G. Rinaldi, G. Viticchi, F. Pellegrini
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/659273
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