background Primary prevention represents the best treatment for cardiovascular(CV) diseases.Especially among younger patients non-pharmacologic approaches are frequently underused.We started aproject of in-hospital physical activity program for primary prevention among high-risk patients.Aims To evaluate metabolic and vascular derangement among conside-red-healthy overweight subjects before a 3 months-course of in-hospital physical activity.Methods 70 consecutive obese patients with no history of acute vascu-lar events(IMA,stroke/TIA or peripheral artery disease)or other diagno-sed comorbidities were enrolled.Each patient underwent to completemetabolic/cardiovascular evaluation before physical activity.results Baseline characteristics were a mean age of 56.8±8.91 years(M:F 2:1,7),BMI of 34.2±5.69g/m2.CV familiarity was present in 45%,hypertension in 64.3%,smoke in 16.7%.We observed high prevalence of insulin resistance(HOMA Index 7.21±6.44) and hypertriglyceridemia;preclinicalmarkers showed endothelial dysfunction (FMD 7.43±10.4%) and high prevalence of increased IMT(30% of the sample);echocardiography showedan increased left ventricle mass(MVSI 108.2±34.0g/m2);double product at stress testresul-ted within lower limits (25.857±6.023).Framingham risk was 14.8%,with a 13.8% comparative increase.conclusions In this sample of italian obese patients we observed a high prevalence of endothelial dysfunction,insulin-resistance,hypertension with end-organ damage with an increased risk for CAD.Paradoxically,we should apply an aggressive therapy for these “healthy”,high-risk,subjects
Metabolic and vascular alterations in “healthy” overweight subjects
L. Falsetti
Writing – Original Draft Preparation
;
2012
Abstract
background Primary prevention represents the best treatment for cardiovascular(CV) diseases.Especially among younger patients non-pharmacologic approaches are frequently underused.We started aproject of in-hospital physical activity program for primary prevention among high-risk patients.Aims To evaluate metabolic and vascular derangement among conside-red-healthy overweight subjects before a 3 months-course of in-hospital physical activity.Methods 70 consecutive obese patients with no history of acute vascu-lar events(IMA,stroke/TIA or peripheral artery disease)or other diagno-sed comorbidities were enrolled.Each patient underwent to completemetabolic/cardiovascular evaluation before physical activity.results Baseline characteristics were a mean age of 56.8±8.91 years(M:F 2:1,7),BMI of 34.2±5.69g/m2.CV familiarity was present in 45%,hypertension in 64.3%,smoke in 16.7%.We observed high prevalence of insulin resistance(HOMA Index 7.21±6.44) and hypertriglyceridemia;preclinicalmarkers showed endothelial dysfunction (FMD 7.43±10.4%) and high prevalence of increased IMT(30% of the sample);echocardiography showedan increased left ventricle mass(MVSI 108.2±34.0g/m2);double product at stress testresul-ted within lower limits (25.857±6.023).Framingham risk was 14.8%,with a 13.8% comparative increase.conclusions In this sample of italian obese patients we observed a high prevalence of endothelial dysfunction,insulin-resistance,hypertension with end-organ damage with an increased risk for CAD.Paradoxically,we should apply an aggressive therapy for these “healthy”,high-risk,subjectsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.