Background:Concentration of serum uric acid(SUA)has been asso-ciated with several cardiovascular diseases. Recent evidences showthat SUA concentration increases after acute ischemic stroke(AS).Aims: evaluate relationships among SUA, renal function, survival anddays of hospitalization in patients admitted to Internal Medicine De-partments(IMD).Methods:We retrospectively enrolled 651elderly patients affected byAS, in the acute phase. History, cardiovascular risk factors, serum levelsof creatinine and SUA, days of hospitalization and mortality were col-lected for each patient. Risk was evaluated with binary logistic regres-sion, while survival was analyzed with Kaplan-Meier and Cox’sRegression models. Multivariate models accounted for vascular riskfactors, NIHSS at arrival, renal function, age and sex as covariates.Results:Mean days of admission for AS in our IMD was8.20±5.09days. A one-unit increase in SUA levels increased the riskof in-hospital death of 1.43times(95% CI:1.20-1.70; p<0.001)in bi-nary logistic regression. Presence of SUA levels above 4.5mg/dl in-creased risk of in-hospital mortality of 2.79 time s(95% CI:1.02-7.60;p<0.05)in the Cox regression model. Moreover, SUA levels >4.5mg/dlwere associated to longer in-hospital stay and higher mortality at Ka-plan-Meier model (SUA levels≤ 4.5mg/dl:23.1days,95%CI:22.33-23.89;SUA levels>4.5mg/dl:52.9 days,95%CI:39.3-66.4;p<0.006 atLog-Rank Test).Discussion: In this sample of elderly, internistic patients affected byAS, SUA levels seem to be independently associated to in-hospitaldeath and longer hospitalization.
Serum uric acid levels and acute stroke: is there a link?
L. FalsettiWriting – Original Draft Preparation
;
2014
Abstract
Background:Concentration of serum uric acid(SUA)has been asso-ciated with several cardiovascular diseases. Recent evidences showthat SUA concentration increases after acute ischemic stroke(AS).Aims: evaluate relationships among SUA, renal function, survival anddays of hospitalization in patients admitted to Internal Medicine De-partments(IMD).Methods:We retrospectively enrolled 651elderly patients affected byAS, in the acute phase. History, cardiovascular risk factors, serum levelsof creatinine and SUA, days of hospitalization and mortality were col-lected for each patient. Risk was evaluated with binary logistic regres-sion, while survival was analyzed with Kaplan-Meier and Cox’sRegression models. Multivariate models accounted for vascular riskfactors, NIHSS at arrival, renal function, age and sex as covariates.Results:Mean days of admission for AS in our IMD was8.20±5.09days. A one-unit increase in SUA levels increased the riskof in-hospital death of 1.43times(95% CI:1.20-1.70; p<0.001)in bi-nary logistic regression. Presence of SUA levels above 4.5mg/dl in-creased risk of in-hospital mortality of 2.79 time s(95% CI:1.02-7.60;p<0.05)in the Cox regression model. Moreover, SUA levels >4.5mg/dlwere associated to longer in-hospital stay and higher mortality at Ka-plan-Meier model (SUA levels≤ 4.5mg/dl:23.1days,95%CI:22.33-23.89;SUA levels>4.5mg/dl:52.9 days,95%CI:39.3-66.4;p<0.006 atLog-Rank Test).Discussion: In this sample of elderly, internistic patients affected byAS, SUA levels seem to be independently associated to in-hospitaldeath and longer hospitalization.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
