PURPOSE OF REVIEW: This study reviews the available literature to compare the accuracy of areal bone mineral density derived from dual X-ray absorptiometry (DXA-aBMD) and of subject-specific finite element models derived from quantitative computed tomography (QCT-SSFE) in predicting bone strength measured experimentally on cadaver bones, as well as their clinical accuracy both in terms of discrimination and prediction. Based on this information, some basic cost-effectiveness calculations are performed to explore the use of QCT-SSFE instead of DXA-aBMD in (a) clinical studies with femoral strength as endpoint, (b) predictor of the risk of hip fracture in low bone mass patients. RECENT FINDINGS: Recent improvements involving the use of smooth-boundary meshes, better anatomical referencing for proximal-only scans, multiple side-fall directions, and refined boundary conditions increase the predictive accuracy of QCT-SSFE. If these improvements are adopted, QCT-SSFE is always preferable over DXA-aBMD in clinical studies with femoral strength as the endpoint, while it is not yet cost-effective as a hip fracture risk predictor, although pathways that combine both QCT-SSFE and DXA-aBMD are promising.

Viceconti, M., Qasim, M., Bhattacharya, P., Li, X. (2018). Are CT-Based Finite Element Model Predictions of Femoral Bone Strengthening Clinically Useful?. CURRENT OSTEOPOROSIS REPORTS, 16(3), 216-223 [10.1007/s11914-018-0438-8].

Are CT-Based Finite Element Model Predictions of Femoral Bone Strengthening Clinically Useful?

Viceconti, M.
Writing – Original Draft Preparation
;
2018

Abstract

PURPOSE OF REVIEW: This study reviews the available literature to compare the accuracy of areal bone mineral density derived from dual X-ray absorptiometry (DXA-aBMD) and of subject-specific finite element models derived from quantitative computed tomography (QCT-SSFE) in predicting bone strength measured experimentally on cadaver bones, as well as their clinical accuracy both in terms of discrimination and prediction. Based on this information, some basic cost-effectiveness calculations are performed to explore the use of QCT-SSFE instead of DXA-aBMD in (a) clinical studies with femoral strength as endpoint, (b) predictor of the risk of hip fracture in low bone mass patients. RECENT FINDINGS: Recent improvements involving the use of smooth-boundary meshes, better anatomical referencing for proximal-only scans, multiple side-fall directions, and refined boundary conditions increase the predictive accuracy of QCT-SSFE. If these improvements are adopted, QCT-SSFE is always preferable over DXA-aBMD in clinical studies with femoral strength as the endpoint, while it is not yet cost-effective as a hip fracture risk predictor, although pathways that combine both QCT-SSFE and DXA-aBMD are promising.
2018
Viceconti, M., Qasim, M., Bhattacharya, P., Li, X. (2018). Are CT-Based Finite Element Model Predictions of Femoral Bone Strengthening Clinically Useful?. CURRENT OSTEOPOROSIS REPORTS, 16(3), 216-223 [10.1007/s11914-018-0438-8].
Viceconti, M.; Qasim, M.; Bhattacharya, P.; Li, X.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/658489
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