A novel catalytic enantioselective methodology based on synergistic catalysis for the synthesis of chiral 2-acyl pyridines and pyrazines is reported. The strategy involves the metal–Lewis acid activation of acetyl aza-arenes and the secondary-amine activation of enals. The proposed mechanism is supported by DFT calculations.
Synergistic Catalysis: Highly Enantioselective Acetyl Aza-arene Addition to Enals / Meazza, Marta; Sitinova, Gabriela; Poderi, Cecilia; Mancinelli, Michele; Zhang, Kaiheng; Mazzanti, Andrea*; Torres, Ramon Rios. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - STAMPA. - 24:50(2018), pp. 201802303.13306-201802303.13310. [10.1002/chem.201802303]
Synergistic Catalysis: Highly Enantioselective Acetyl Aza-arene Addition to Enals
PODERI, CECILIA;Mancinelli, Michele;Mazzanti, Andrea
;
2018
Abstract
A novel catalytic enantioselective methodology based on synergistic catalysis for the synthesis of chiral 2-acyl pyridines and pyrazines is reported. The strategy involves the metal–Lewis acid activation of acetyl aza-arenes and the secondary-amine activation of enals. The proposed mechanism is supported by DFT calculations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
