A novel catalytic enantioselective methodology based on synergistic catalysis for the synthesis of chiral 2-acyl pyridines and pyrazines is reported. The strategy involves the metal–Lewis acid activation of acetyl aza-arenes and the secondary-amine activation of enals. The proposed mechanism is supported by DFT calculations.
Meazza, M., Sitinova, G., Poderi, C., Mancinelli, M., Zhang, K., Mazzanti, A., et al. (2018). Synergistic Catalysis: Highly Enantioselective Acetyl Aza-arene Addition to Enals. CHEMISTRY-A EUROPEAN JOURNAL, 24(50), 13306-13310 [10.1002/chem.201802303].
Synergistic Catalysis: Highly Enantioselective Acetyl Aza-arene Addition to Enals
PODERI, CECILIA;Mancinelli, Michele;Mazzanti, Andrea
;
2018
Abstract
A novel catalytic enantioselective methodology based on synergistic catalysis for the synthesis of chiral 2-acyl pyridines and pyrazines is reported. The strategy involves the metal–Lewis acid activation of acetyl aza-arenes and the secondary-amine activation of enals. The proposed mechanism is supported by DFT calculations.File in questo prodotto:
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