The Fisher esterification reaction has been exploited for linking a peptide (chlorotoxin) onto the surface of nanocellulose using a Brønsted acid ionic liquid both as a solvent and a catalyst. Indeed, cellulose nanocrystals were functionalized with the peptide thanks to a mild, one-step and organic solvent-free reaction. The obtained nanocellulose showed excellent properties in terms of biocompatibility and internalization in the U87MG glioblastoma cell line, thus demonstrating the possible use of this material as a novel drug delivery carrier.
One-step esterification of nanocellulose in Brønsted acid Ionic Liquid for delivery to Glioblastoma Cancer cells
CELLANTE, LINA;Costa, Roberta;Monaco, Ilaria;CENACCHI, GIOVANNA;Locatelli, Erica
2018
Abstract
The Fisher esterification reaction has been exploited for linking a peptide (chlorotoxin) onto the surface of nanocellulose using a Brønsted acid ionic liquid both as a solvent and a catalyst. Indeed, cellulose nanocrystals were functionalized with the peptide thanks to a mild, one-step and organic solvent-free reaction. The obtained nanocellulose showed excellent properties in terms of biocompatibility and internalization in the U87MG glioblastoma cell line, thus demonstrating the possible use of this material as a novel drug delivery carrier.File in questo prodotto:
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