The Fisher esterification reaction has been exploited for linking a peptide (chlorotoxin) onto the surface of nanocellulose using a Brønsted acid ionic liquid both as a solvent and a catalyst. Indeed, cellulose nanocrystals were functionalized with the peptide thanks to a mild, one-step and organic solvent-free reaction. The obtained nanocellulose showed excellent properties in terms of biocompatibility and internalization in the U87MG glioblastoma cell line, thus demonstrating the possible use of this material as a novel drug delivery carrier.
Cellante, L., Costa, R., Monaco, I., CENACCHI, G., Locatelli, E. (2018). One-step esterification of nanocellulose in Brønsted acid Ionic Liquid for delivery to Glioblastoma Cancer cells. NEW JOURNAL OF CHEMISTRY, 42, 5237-5242 [10.1039/C7NJ04633B].
One-step esterification of nanocellulose in Brønsted acid Ionic Liquid for delivery to Glioblastoma Cancer cells
CELLANTE, LINA;Costa, Roberta;Monaco, Ilaria;CENACCHI, GIOVANNA;Locatelli, Erica
2018
Abstract
The Fisher esterification reaction has been exploited for linking a peptide (chlorotoxin) onto the surface of nanocellulose using a Brønsted acid ionic liquid both as a solvent and a catalyst. Indeed, cellulose nanocrystals were functionalized with the peptide thanks to a mild, one-step and organic solvent-free reaction. The obtained nanocellulose showed excellent properties in terms of biocompatibility and internalization in the U87MG glioblastoma cell line, thus demonstrating the possible use of this material as a novel drug delivery carrier.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
