A new protocol for the enantioselective direct alpha-heteroarylation of aldehydes with isoquinoline N-oxides, via chiral enamine catalysis, has been successfully developed. High enantiomeric excesses and moderate to good yields were achieved for a variety of alpha-heteroarylated aldehydes.
Bertuzzi, G., Pecorari, D., Bernardi, L., Fochi, M. (2018). An organocatalytic enantioselective direct alpha-heteroarylation of aldehydes with isoquinoline N-oxides. CHEMICAL COMMUNICATIONS, 54(32), 3977-3980 [10.1039/c8cc01735b].
An organocatalytic enantioselective direct alpha-heteroarylation of aldehydes with isoquinoline N-oxides
Bertuzzi, Giulio;PECORARI, DANIEL;Bernardi, Luca
;Fochi, Mariafrancesca
2018
Abstract
A new protocol for the enantioselective direct alpha-heteroarylation of aldehydes with isoquinoline N-oxides, via chiral enamine catalysis, has been successfully developed. High enantiomeric excesses and moderate to good yields were achieved for a variety of alpha-heteroarylated aldehydes.File in questo prodotto:
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