An innovative epidermal surface treatment based on 188Re has been recently developed for squamous cell carcinomas of the skin. The planning and delivery of the treatment requires an accurate knowledge of the source activity and thus proper calibration of activity meters. However, reference sources for calibration purposes are not always available, as in the case of short-lived radionuclides. The aim of this work is to determine the calibration factors for 188Re by comparison of measurements with an independently calibrated HPGe spectrometer. Calibration factors were experimentally determined for two different activity meters, a Capintec CRC15 and a MecMurphil MP-DC. This study was conducted on a Rhenium-188 compound produced by OncoBeta® GmbH for Rhenium-SCT® therapy. The final calibration factors, relative to 137Cs, for the MecMurphil MP-DC were: 4.35 ± 0.06 for point-like sources and 4.48 ± 0.09 for 5 mL solutions. While the final calibration factors for the Capintec CRC15 were: 4.12 ± 0.07 for point-like sources and 4.60 ± 0.10 for 5 mL solutions. With the presented method, we managed to determine calibration factors with an uncertainty below 3%.
Liverani, S., Vichi, S., Zagni, F., Riga, S., Lima, G., Castellucci, P., et al. (2018). Determination of the activity meter calibration factor for Rhenium-188. RADIATION EFFECTS AND DEFECTS IN SOLIDS, 173(9-10), 758-762 [10.1080/10420150.2018.1528601].
Determination of the activity meter calibration factor for Rhenium-188
Vichi, S.;Mostacci, D.
2018
Abstract
An innovative epidermal surface treatment based on 188Re has been recently developed for squamous cell carcinomas of the skin. The planning and delivery of the treatment requires an accurate knowledge of the source activity and thus proper calibration of activity meters. However, reference sources for calibration purposes are not always available, as in the case of short-lived radionuclides. The aim of this work is to determine the calibration factors for 188Re by comparison of measurements with an independently calibrated HPGe spectrometer. Calibration factors were experimentally determined for two different activity meters, a Capintec CRC15 and a MecMurphil MP-DC. This study was conducted on a Rhenium-188 compound produced by OncoBeta® GmbH for Rhenium-SCT® therapy. The final calibration factors, relative to 137Cs, for the MecMurphil MP-DC were: 4.35 ± 0.06 for point-like sources and 4.48 ± 0.09 for 5 mL solutions. While the final calibration factors for the Capintec CRC15 were: 4.12 ± 0.07 for point-like sources and 4.60 ± 0.10 for 5 mL solutions. With the presented method, we managed to determine calibration factors with an uncertainty below 3%.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
