An innovative epidermal surface treatment based on 188Re has been recently developed for squamous cell carcinomas of the skin. The planning and delivery of the treatment requires an accurate knowledge of the source activity and thus proper calibration of activity meters. However, reference sources for calibration purposes are not always available, as in the case of short-lived radionuclides. The aim of this work is to determine the calibration factors for 188Re by comparison of measurements with an independently calibrated HPGe spectrometer. Calibration factors were experimentally determined for two different activity meters, a Capintec CRC15 and a MecMurphil MP-DC. This study was conducted on a Rhenium-188 compound produced by OncoBeta® GmbH for Rhenium-SCT® therapy. The final calibration factors, relative to 137Cs, for the MecMurphil MP-DC were: 4.35 ± 0.06 for point-like sources and 4.48 ± 0.09 for 5 mL solutions. While the final calibration factors for the Capintec CRC15 were: 4.12 ± 0.07 for point-like sources and 4.60 ± 0.10 for 5 mL solutions. With the presented method, we managed to determine calibration factors with an uncertainty below 3%.

Liverani, S., Vichi, S., Zagni, F., Riga, S., Lima, G., Castellucci, P., et al. (2018). Determination of the activity meter calibration factor for Rhenium-188. RADIATION EFFECTS AND DEFECTS IN SOLIDS, 173(9-10), 758-762 [10.1080/10420150.2018.1528601].

Determination of the activity meter calibration factor for Rhenium-188

Vichi, S.;Mostacci, D.
2018

Abstract

An innovative epidermal surface treatment based on 188Re has been recently developed for squamous cell carcinomas of the skin. The planning and delivery of the treatment requires an accurate knowledge of the source activity and thus proper calibration of activity meters. However, reference sources for calibration purposes are not always available, as in the case of short-lived radionuclides. The aim of this work is to determine the calibration factors for 188Re by comparison of measurements with an independently calibrated HPGe spectrometer. Calibration factors were experimentally determined for two different activity meters, a Capintec CRC15 and a MecMurphil MP-DC. This study was conducted on a Rhenium-188 compound produced by OncoBeta® GmbH for Rhenium-SCT® therapy. The final calibration factors, relative to 137Cs, for the MecMurphil MP-DC were: 4.35 ± 0.06 for point-like sources and 4.48 ± 0.09 for 5 mL solutions. While the final calibration factors for the Capintec CRC15 were: 4.12 ± 0.07 for point-like sources and 4.60 ± 0.10 for 5 mL solutions. With the presented method, we managed to determine calibration factors with an uncertainty below 3%.
2018
Liverani, S., Vichi, S., Zagni, F., Riga, S., Lima, G., Castellucci, P., et al. (2018). Determination of the activity meter calibration factor for Rhenium-188. RADIATION EFFECTS AND DEFECTS IN SOLIDS, 173(9-10), 758-762 [10.1080/10420150.2018.1528601].
Liverani, S.; Vichi, S.*; Zagni, F.; Riga, S.; Lima, G.M.; Castellucci, P.; Wendler, T.; Olmeda, M.; Marengo, M.; Mostacci, D.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/656376
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact