The strategy of single-molecule mechanical unfolding of multimodular proteins is extended to the investigation of any chemical bond by an appropriately tailored, comblike polymer bearing multiple instances of any desired chemical interaction or bond to be studied along its linear chain. This approach is used to study the Ni-(His)n-NTA complex.
F. Valle, G. Zuccheri, A. Bergia, L. Ayres, A. E. Rowan, R. J. M. Nolte, et al. (2008). A polymeric molecular "Handle" for multiple AFM-based single-molecule force measurements. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 47, 2431-2434 [10.1002/anie.200704526].
A polymeric molecular "Handle" for multiple AFM-based single-molecule force measurements.
VALLE, FRANCESCO;ZUCCHERI, GIAMPAOLO;BERGIA, ANNA;SAMORI', BRUNO
2008
Abstract
The strategy of single-molecule mechanical unfolding of multimodular proteins is extended to the investigation of any chemical bond by an appropriately tailored, comblike polymer bearing multiple instances of any desired chemical interaction or bond to be studied along its linear chain. This approach is used to study the Ni-(His)n-NTA complex.File in questo prodotto:
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