Diagnostic nanomedicine constantly needs for development of novel contrast agents with intrinsic imaging capability. Phosphorescent Ir(III)-complexes represent good candidates when delivered through polymeric nanoparticles. In this work, we propose a biocompatible nanoparticle made from an intrisically phosphorescent copolymer, synthesized directly with the imaging tag present onto its backbone. Polymeric nanoparticles can be obtained with the exact amount of phosphorescent moiety needed to maximize the output signal. Complete characterization and ex-vivo studies confirmed that this nanosystem is suitable as future diagnostic tool.
Monaco, I., Maturi, M., Matteucci, E., Locatelli, E., Baschieri, A., Zani, P., et al. (2018). Phosphorescent iridium-containing nanomicelles: synthesis, characterization and preliminary applications in nanomedical imaging. RSC ADVANCES, 8(59), 34162-34167 [10.1039/C8RA05368E].
Phosphorescent iridium-containing nanomicelles: synthesis, characterization and preliminary applications in nanomedical imaging
Monaco, I.;Maturi, M.;Matteucci, E.;Locatelli, E.;Baschieri, A.;Zani, P.;Sambri, L.
;Comes Franchini, M.
2018
Abstract
Diagnostic nanomedicine constantly needs for development of novel contrast agents with intrinsic imaging capability. Phosphorescent Ir(III)-complexes represent good candidates when delivered through polymeric nanoparticles. In this work, we propose a biocompatible nanoparticle made from an intrisically phosphorescent copolymer, synthesized directly with the imaging tag present onto its backbone. Polymeric nanoparticles can be obtained with the exact amount of phosphorescent moiety needed to maximize the output signal. Complete characterization and ex-vivo studies confirmed that this nanosystem is suitable as future diagnostic tool.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
