Palatine tonsils (PTs) are replication sites for infectious prions (PrPSc). From the PTs PrPSc take part to neuroinvasion. To study the connections between PTs, central and peripheral nervous system, we injected in the lamb PTs the tracer Fast Blue (FB). FB-labelled neurons were observed in the sympathetic cervical cranial ganglia (CCG), vagal and glossopharingeal ganglia, and trigeminal ganglia (TG). Immunohistochemistry was performed on PTs and ganglia cryosections. FB-labeled sensory neurons expressed NOS-, CGRP-, and SPIR. CCG FB-labeled neurons expressed DBH-IR, but FB-labeled neurons DBH-negative were also observed. The present results provide a plausible anatomic basis through which infectious prions may gain access to the CNS. Immunoreactivity for dopamine-beta-hydroxylase (DBH), nitric oxide synthase (NOS), calcitonin gene-related peptide (CGRP), and substance P (SP) was observed in PTs fibres.
Innervazione delle tonsille palatine nella pecora / RUSSO D.; MONGARDI FANTAGUZZI C.; LUCHERINI M.C.; CLAVENZANI P.; LALATTA COSTERBOSA G.; DI GUARDO G.; CHIOCCHETTI R.. - ELETTRONICO. - LXII:(2008), pp. 29-30. (Intervento presentato al convegno LXII Convegno Nazionale della Società Italiana delle Scienze Veterinarie tenutosi a S. Benedetto del Tronto nel 24-26 settembre 2008).
Innervazione delle tonsille palatine nella pecora
RUSSO, DOMENICO;CLAVENZANI, PAOLO;LALATTA COSTERBOSA, GIOVANNA;CHIOCCHETTI, ROBERTO
2008
Abstract
Palatine tonsils (PTs) are replication sites for infectious prions (PrPSc). From the PTs PrPSc take part to neuroinvasion. To study the connections between PTs, central and peripheral nervous system, we injected in the lamb PTs the tracer Fast Blue (FB). FB-labelled neurons were observed in the sympathetic cervical cranial ganglia (CCG), vagal and glossopharingeal ganglia, and trigeminal ganglia (TG). Immunohistochemistry was performed on PTs and ganglia cryosections. FB-labeled sensory neurons expressed NOS-, CGRP-, and SPIR. CCG FB-labeled neurons expressed DBH-IR, but FB-labeled neurons DBH-negative were also observed. The present results provide a plausible anatomic basis through which infectious prions may gain access to the CNS. Immunoreactivity for dopamine-beta-hydroxylase (DBH), nitric oxide synthase (NOS), calcitonin gene-related peptide (CGRP), and substance P (SP) was observed in PTs fibres.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.