In Sweden, human tissue samples obtained from diagnostic and surgical procedures have for decades been routinely stored in a formalin-fixed, paraffin-embedded, form. Through linkage with nationwide registers, these samples are available for molecular studies to identify biomarkers predicting mortality even in slow-progressing prostate cancer. However, tissue fixation causes modifications of nucleic acids, making it challenging to extract high-quality nucleic acids from formalin fixated tissues.

Quantity and quality of nucleic acids extracted from archival formalin fixed paraffin embedded prostate biopsies

Fiorentino, Michelangelo;
2018

Abstract

In Sweden, human tissue samples obtained from diagnostic and surgical procedures have for decades been routinely stored in a formalin-fixed, paraffin-embedded, form. Through linkage with nationwide registers, these samples are available for molecular studies to identify biomarkers predicting mortality even in slow-progressing prostate cancer. However, tissue fixation causes modifications of nucleic acids, making it challenging to extract high-quality nucleic acids from formalin fixated tissues.
2018
Carlsson, Jessica; Davidsson, Sabina; Fridfeldt, Jonna; Giunchi, Francesca; Fiano, Valentina; Grasso, Chiara; Zelic, Renata; Richiardi, Lorenzo; Andrén, Ove; Pettersson, Andreas; Fiorentino, Michelangelo; Akre, Olof
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/651998
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