Lymph node (LN) metastasis in canine cutaneous mast cell tumours (cMCTs) is a well-known negative prognostic factor. The role of lymphadenectomy in the treatment of stage II disease remains controversial because of its uncertain therapeutic benefit. Aim of this retrospective study was to investigate the impact of lymphadenectomy on tumour control and survival for dogs with stage II cMCTs. Dogs with firstly occurring, histologically confirmed cMCT with LN metastasis undergoing resection of the primary tumour and medical treatment thereafter were retrospectively enrolled. Dogs were classified into two groups: LN sampling (LNS; diagnosis of metastasis obtained by cytology) and regional LN dissection (LND; diagnosis obtained by histopathology). To determine the therapeutic value of lymphadenectomy, the characteristics of recurrence (local, nodal and distant) and survival were compared between groups. Evaluated outcome variables included signalment, anatomic location, diameter, ulceration, substage, surgical margins, Patnaik grading, Kiupel grading and medical treatment. Overall, 152 dogs were included: 81 underwent LND as part of primary surgery and 71 LNS. The median follow-up time was 409 days for LND group and 620 days for LNS group. On univariable analysis, the risk of developing local, nodal or distant relapse was significantly higher in the LNS group compared with LND (P < 0.001). On multivariable analysis, the risk of tumour progression and tumour-related death were 5.47 and 3.61 times higher in the LNS group, respectively (P < 0.001). Regional lymphadenectomy may have therapeutic value and improve prognosis in dogs with stage II cMCTs undergoing surgical removal of the primary tumour and medical treatment.

Therapeutic impact of regional lymphadenectomy in canine stage II cutaneous mast cell tumours / Marconato, Laura*; Polton, Gerry; Stefanello, Damiano; Morello, Emanuela; Ferrari, Roberta; Henriques, Joaquim; Tortorella, Giovanni; Benali, Silvia L.; Bergottini, Raffaella; Vasconi, Maria E.; Annoni, Maurizio; Sabattini, Silvia. - In: VETERINARY AND COMPARATIVE ONCOLOGY. - ISSN 1476-5810. - STAMPA. - 16:4(2018), pp. 580-589. [10.1111/vco.12425]

Therapeutic impact of regional lymphadenectomy in canine stage II cutaneous mast cell tumours

Marconato, Laura
;
Sabattini, Silvia
2018

Abstract

Lymph node (LN) metastasis in canine cutaneous mast cell tumours (cMCTs) is a well-known negative prognostic factor. The role of lymphadenectomy in the treatment of stage II disease remains controversial because of its uncertain therapeutic benefit. Aim of this retrospective study was to investigate the impact of lymphadenectomy on tumour control and survival for dogs with stage II cMCTs. Dogs with firstly occurring, histologically confirmed cMCT with LN metastasis undergoing resection of the primary tumour and medical treatment thereafter were retrospectively enrolled. Dogs were classified into two groups: LN sampling (LNS; diagnosis of metastasis obtained by cytology) and regional LN dissection (LND; diagnosis obtained by histopathology). To determine the therapeutic value of lymphadenectomy, the characteristics of recurrence (local, nodal and distant) and survival were compared between groups. Evaluated outcome variables included signalment, anatomic location, diameter, ulceration, substage, surgical margins, Patnaik grading, Kiupel grading and medical treatment. Overall, 152 dogs were included: 81 underwent LND as part of primary surgery and 71 LNS. The median follow-up time was 409 days for LND group and 620 days for LNS group. On univariable analysis, the risk of developing local, nodal or distant relapse was significantly higher in the LNS group compared with LND (P < 0.001). On multivariable analysis, the risk of tumour progression and tumour-related death were 5.47 and 3.61 times higher in the LNS group, respectively (P < 0.001). Regional lymphadenectomy may have therapeutic value and improve prognosis in dogs with stage II cMCTs undergoing surgical removal of the primary tumour and medical treatment.
2018
Therapeutic impact of regional lymphadenectomy in canine stage II cutaneous mast cell tumours / Marconato, Laura*; Polton, Gerry; Stefanello, Damiano; Morello, Emanuela; Ferrari, Roberta; Henriques, Joaquim; Tortorella, Giovanni; Benali, Silvia L.; Bergottini, Raffaella; Vasconi, Maria E.; Annoni, Maurizio; Sabattini, Silvia. - In: VETERINARY AND COMPARATIVE ONCOLOGY. - ISSN 1476-5810. - STAMPA. - 16:4(2018), pp. 580-589. [10.1111/vco.12425]
Marconato, Laura*; Polton, Gerry; Stefanello, Damiano; Morello, Emanuela; Ferrari, Roberta; Henriques, Joaquim; Tortorella, Giovanni; Benali, Silvia L.; Bergottini, Raffaella; Vasconi, Maria E.; Annoni, Maurizio; Sabattini, Silvia
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/651804
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 54
  • ???jsp.display-item.citation.isi??? 51
social impact