We present soft spider array for gentle contact mode scanning electrochemical microscopy (SECM) imaging of tissues. The spider array contains up to eight completely individual, parallel, and flexible carbon microelectrodes designed to scan square centimeter sized areas on reasonable time scales while avoiding sample aging and electrode fouling. The contact mode enables the scanning of largely curved samples at a constant distance. The spider array is applied for the SECM imaging of the distribution of certain biomarkers, such as tyrosinase, in thin tumor tissues as well as thick tumor blocks. Furthermore, the spider array can be applied for mapping the antioxidant distribution in an apple peel.
Soft probe scanning electrochemical microscopy with spider array for visualizing biomarkers and redox active proteins in animal tissues / Lin, Tzu-En; Lu, Yu-Jen; Sun, Chia-Liang; Chen, Jyh-Ping; Lesch, Andreas; Girault, Hubert H.. - In: ECS TRANSACTIONS. - ISSN 1938-5862. - ELETTRONICO. - 77:7(2017), pp. 85-90. (Intervento presentato al convegno Symposium on Solid-State Electronics and Photonics in Biology and Medicine 4 - 231st ECS Meeting 2017 tenutosi a USA nel 2017) [10.1149/07707.0085ecst].
Soft probe scanning electrochemical microscopy with spider array for visualizing biomarkers and redox active proteins in animal tissues
Lesch, Andreas;
2017
Abstract
We present soft spider array for gentle contact mode scanning electrochemical microscopy (SECM) imaging of tissues. The spider array contains up to eight completely individual, parallel, and flexible carbon microelectrodes designed to scan square centimeter sized areas on reasonable time scales while avoiding sample aging and electrode fouling. The contact mode enables the scanning of largely curved samples at a constant distance. The spider array is applied for the SECM imaging of the distribution of certain biomarkers, such as tyrosinase, in thin tumor tissues as well as thick tumor blocks. Furthermore, the spider array can be applied for mapping the antioxidant distribution in an apple peel.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
