The effects of Castanea sativa Mill. have been studied in high fat diet (HFD) overweight rats. Natural Extract of Chestnut bark (Castanea sativa Mill.) (ENC®), rich in ellagitannins, has been studied in 120 male Sprague-Dawley rats, divided in four groups. Two groups were controls: regular (RD) and HDF diet. Two groups received ENC®(20 mg/kg/day): RD + ENC®and HFD + ENC®. At baseline and at 7, 14 and 21 days, weight gain, serum lipids, plasma cytokines, liver histology, microsomial enzymes and oxidation, intestinal oxidative stress and contractility were studied. HFD increased body weight, increased pro-inflammatory cytokines, induced hepatocytes microvescicular steatosis, altered microsomial, increased liver and intestinal oxidative stress, deranged intestinal contractility. In HFD-fed rats, ENC®exerted antiadipose and antioxidative activities and normalized intestinal contractility, suggesting a potential approach to overweight management associated diseases.

Budriesi, R., Vivarelli, F., Canistro, D., Aldini, R., Marquillas, C.B., Corazza, I., et al. (2018). Liver and intestinal protective effects of Castanea sativa Mill. bark extract in high-fat diet rats. PLOS ONE, 13(8), 1-19 [10.1371/journal.pone.0201540].

Liver and intestinal protective effects of Castanea sativa Mill. bark extract in high-fat diet rats

Budriesi, Roberta;Vivarelli, Fabio;Canistro, Donatella
;
Aldini, Rita;Corazza, Ivan;Fato, Romana;Cirillo, Silvia;Bergamini, Christian;D’Errico, Antonia;Cevenini, Monica;Chiarini, Alberto;Micucci, Matteo
2018

Abstract

The effects of Castanea sativa Mill. have been studied in high fat diet (HFD) overweight rats. Natural Extract of Chestnut bark (Castanea sativa Mill.) (ENC®), rich in ellagitannins, has been studied in 120 male Sprague-Dawley rats, divided in four groups. Two groups were controls: regular (RD) and HDF diet. Two groups received ENC®(20 mg/kg/day): RD + ENC®and HFD + ENC®. At baseline and at 7, 14 and 21 days, weight gain, serum lipids, plasma cytokines, liver histology, microsomial enzymes and oxidation, intestinal oxidative stress and contractility were studied. HFD increased body weight, increased pro-inflammatory cytokines, induced hepatocytes microvescicular steatosis, altered microsomial, increased liver and intestinal oxidative stress, deranged intestinal contractility. In HFD-fed rats, ENC®exerted antiadipose and antioxidative activities and normalized intestinal contractility, suggesting a potential approach to overweight management associated diseases.
2018
Budriesi, R., Vivarelli, F., Canistro, D., Aldini, R., Marquillas, C.B., Corazza, I., et al. (2018). Liver and intestinal protective effects of Castanea sativa Mill. bark extract in high-fat diet rats. PLOS ONE, 13(8), 1-19 [10.1371/journal.pone.0201540].
Budriesi, Roberta; Vivarelli, Fabio; Canistro, Donatella*; Aldini, Rita; Marquillas, Clara Babot; Corazza, Ivan; Fato, Romana; Cirillo, Silvia; Bergam...espandi
File in questo prodotto:
File Dimensione Formato  
pone.0201540.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione 11.58 MB
Formato Adobe PDF
11.58 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/649352
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 13
social impact