Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized. Among them, TRP-melastatin 2 (TRPM2) is particularly involved in the response to oxidative stress and inflammation, while its activity depends on the presence of intracellular calcium (Ca2+). TRPM2 is involved in several physiological and pathological processes in the brain through the modulation of multiple signaling pathways. The aim of the present review is to provide a brief summary of the current insights of TRPM2 role in health and disease to focalize our attention on future potential neuroprotective strategies.
TRPM2 in the Brain: Role in Health and Disease / Sita, Giulia; Hrelia, Patrizia; Graziosi, Agnese; Ravegnini, Gloria; Morroni, Fabiana. - In: CELLS. - ISSN 2073-4409. - ELETTRONICO. - 7:7(2018), pp. 82.1-82.13. [10.3390/cells7070082]
TRPM2 in the Brain: Role in Health and Disease
Sita, Giulia;Hrelia, Patrizia
;Graziosi, Agnese;Ravegnini, Gloria;Morroni, Fabiana
2018
Abstract
Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized. Among them, TRP-melastatin 2 (TRPM2) is particularly involved in the response to oxidative stress and inflammation, while its activity depends on the presence of intracellular calcium (Ca2+). TRPM2 is involved in several physiological and pathological processes in the brain through the modulation of multiple signaling pathways. The aim of the present review is to provide a brief summary of the current insights of TRPM2 role in health and disease to focalize our attention on future potential neuroprotective strategies.File | Dimensione | Formato | |
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