The prevalence of H pylori varies widely and is about 50% in international population studies Triple and quadruple multidrug regimens are standard treatment Resistance to clarithromycin and metronidazole and lack of adherence to treatment are the main predictors of treatment failure The choice of the most effective regimen should be based on the prevalence of antibiotic resistance, especially resistance to clarithromycin and metronidazole Individualised treatment based on antimicrobial susceptibility has a limited role in H pylori eradication strategies The overall risk of reinfection is estimated at 3.4% per patient year in developed countries, rising to 8.7% in developing countries
L Fuccio, L Laterza, R M Zagari, V Cennamo, D Grilli, and Franco Bazzoli (2008). Treatment of Helicobacter pylori infection. BMJ. BRITISH MEDICAL JOURNAL, 337, 746-750 [10.1136/bmj.a1454].
Treatment of Helicobacter pylori infection
FUCCIO, LORENZO;ZAGARI, ROCCO MAURIZIO;BAZZOLI, FRANCO
2008
Abstract
The prevalence of H pylori varies widely and is about 50% in international population studies Triple and quadruple multidrug regimens are standard treatment Resistance to clarithromycin and metronidazole and lack of adherence to treatment are the main predictors of treatment failure The choice of the most effective regimen should be based on the prevalence of antibiotic resistance, especially resistance to clarithromycin and metronidazole Individualised treatment based on antimicrobial susceptibility has a limited role in H pylori eradication strategies The overall risk of reinfection is estimated at 3.4% per patient year in developed countries, rising to 8.7% in developing countriesI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
