we have discovered a novel strategy for the enamine-catalyzed formal alfa-alkylation of aldehydes. The use of L-proline allows easy access to relevant 3-indolyl derivatives with high diastereo- and enantiocontrol, affording an easy alternative to the classical Friedel–Crafts route to these compounds
R. R. Shaikh, A. Mazzanti, M. Petrini, G. Bartoli, P. Melchiorre (2008). Proline Catalyzed Asymmetric Formal alfa-Alkylation of Aldehydes via Vinylogous Iminium Ion Intermediate Generated from Arylsulfonyl Indoles. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 478707, 8707-8710 [10.1002/anie.200803947].
Proline Catalyzed Asymmetric Formal alfa-Alkylation of Aldehydes via Vinylogous Iminium Ion Intermediate Generated from Arylsulfonyl Indoles
MAZZANTI, ANDREA;BARTOLI, GIUSEPPE;MELCHIORRE, PAOLO
2008
Abstract
we have discovered a novel strategy for the enamine-catalyzed formal alfa-alkylation of aldehydes. The use of L-proline allows easy access to relevant 3-indolyl derivatives with high diastereo- and enantiocontrol, affording an easy alternative to the classical Friedel–Crafts route to these compoundsFile in questo prodotto:
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