we have developed the first aminocatalyzed anti-selective Mannich reaction of aldehydes with N-Cbz- and N-Boc-protected imines generated in situ from stable aamido sulfones 2. Besides the high level of efficiency and stereocontrol achieved, this approach introduces important synthetic advantages, by avoiding the requirement to preform the N-carbamoyl imines.
C. Gianelli, L. Sambri, A. Carlone, G. Bartoli, P. Melchiorre (2008). Aminocatalytic Enantioselective anti-Mannich Reaction of Aldehydes with in Situ Generated N-Cbz and N-Boc Imines. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 47, 8700-8702 [10.1002/anie.200803819].
Aminocatalytic Enantioselective anti-Mannich Reaction of Aldehydes with in Situ Generated N-Cbz and N-Boc Imines
SAMBRI, LETIZIA;CARLONE, ARMANDO;BARTOLI, GIUSEPPE;MELCHIORRE, PAOLO
2008
Abstract
we have developed the first aminocatalyzed anti-selective Mannich reaction of aldehydes with N-Cbz- and N-Boc-protected imines generated in situ from stable aamido sulfones 2. Besides the high level of efficiency and stereocontrol achieved, this approach introduces important synthetic advantages, by avoiding the requirement to preform the N-carbamoyl imines.File in questo prodotto:
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