Review on a very fast moving area of research: Catalysis with chiral secondary amines (asymmetric aminocatalysis) has become a well-established and powerful synthetic tool for the chemo- and enantioselective functionalization of carbonyl compounds. In the last eight years alone, this field has grown at such an extraordinary pace that it is now recognized as an independent area of synthetic chemistry, where the goal is the preparation of any chiral molecule in an efficient, rapid, and stereoselective manner. This has been made possible by the impressive level of scientific competition and high quality research generated in this area. This Review describes this “Asymmetric Aminocatalysis Gold Rush” and charts the milestones in its development. As in all areas of science, progress depends on human effort.

P. Melchiorre, M. Marigo, A. Carlone, G. Bartoli (2008). Asymmetric Aminocatalysis-Gold Rush in Organic Chemistry. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 47, 6138-6171 [10.1002/anie.200705523].

Asymmetric Aminocatalysis-Gold Rush in Organic Chemistry

MELCHIORRE, PAOLO;CARLONE, ARMANDO;BARTOLI, GIUSEPPE
2008

Abstract

Review on a very fast moving area of research: Catalysis with chiral secondary amines (asymmetric aminocatalysis) has become a well-established and powerful synthetic tool for the chemo- and enantioselective functionalization of carbonyl compounds. In the last eight years alone, this field has grown at such an extraordinary pace that it is now recognized as an independent area of synthetic chemistry, where the goal is the preparation of any chiral molecule in an efficient, rapid, and stereoselective manner. This has been made possible by the impressive level of scientific competition and high quality research generated in this area. This Review describes this “Asymmetric Aminocatalysis Gold Rush” and charts the milestones in its development. As in all areas of science, progress depends on human effort.
2008
P. Melchiorre, M. Marigo, A. Carlone, G. Bartoli (2008). Asymmetric Aminocatalysis-Gold Rush in Organic Chemistry. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 47, 6138-6171 [10.1002/anie.200705523].
P. Melchiorre; M. Marigo; A. Carlone; G. Bartoli
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/63927
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1222
  • ???jsp.display-item.citation.isi??? 1176
social impact