An efficient, one-pot multicomponent synthetic protocol toward substituted 1,4-dihydropyridines from aromatic amines, β-keto derivatives, and ethyl propiolate mediated by Mg(ClO4)2 is described. When ortho- or meta-substituted arylamines are used, two conformational isomers are generated. An NMR spectroscopic study of the energy barrier involved in the interconversion of the isomers is reported.
G. Bartoli, M. Bosco, P. Galzerano, R. Giri, A. Mazzanti, P. Melchiorre, et al. (2008). Multicomponent Domino Reaction Promoted by Mg(ClO4)2: Highly Efficient Access to Functionalized 1,4-Dihydropyridines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2008, 3970-3975 [10.1002/ejoc.200800422].
Multicomponent Domino Reaction Promoted by Mg(ClO4)2: Highly Efficient Access to Functionalized 1,4-Dihydropyridines
BARTOLI, GIUSEPPE;BOSCO, MARCELLA;GALZERANO, PATRIZIA;MAZZANTI, ANDREA;MELCHIORRE, PAOLO;SAMBRI, LETIZIA
2008
Abstract
An efficient, one-pot multicomponent synthetic protocol toward substituted 1,4-dihydropyridines from aromatic amines, β-keto derivatives, and ethyl propiolate mediated by Mg(ClO4)2 is described. When ortho- or meta-substituted arylamines are used, two conformational isomers are generated. An NMR spectroscopic study of the energy barrier involved in the interconversion of the isomers is reported.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
