A new metal-free protocol for promoting oxidation of amines in aqueous-organic medium was developed. NaIO4and TEMPO as the catalyst emerged as the most efficient and selective system for oxidation of differently substituted benzyl amines to the corresponding benzaldehydes without overoxidation. Unsymmetrical secondary amines underwent selective oxidation only at the benzylic position thus realising an oxidative deprotection of a benzylic group with an easy amine recovery.
Galletti, P., Martelli, G., Prandini, G., Colucci, C., Giacomini, D. (2018). Sodium periodate/TEMPO as a selective and efficient system for amine oxidation. RSC ADVANCES, 8(18), 9723-9730 [10.1039/c8ra01365a].
Sodium periodate/TEMPO as a selective and efficient system for amine oxidation
Galletti, P.;MARTELLI, GIULIA;PRANDINI, GIULIA;Giacomini, D.
2018
Abstract
A new metal-free protocol for promoting oxidation of amines in aqueous-organic medium was developed. NaIO4and TEMPO as the catalyst emerged as the most efficient and selective system for oxidation of differently substituted benzyl amines to the corresponding benzaldehydes without overoxidation. Unsymmetrical secondary amines underwent selective oxidation only at the benzylic position thus realising an oxidative deprotection of a benzylic group with an easy amine recovery.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
