Nitroalkanes can be profitably employed as carbanionic precursors for theassembly of dihydroxy ketone frameworks, suitable for the preparation of spiroketals. Thecarbon-carbon bond formation is carried out exploiting nitroaldol and Michael reactions,while the nitro to carbonyl conversion (Nef reaction) ensures the correct introduction of theketo group. Several spiroketal systems endowed with considerable biological activity canbe prepared using this synthetic strategy.
R. Ballini, M. Petrini, G. Rosini (2008). Nitroalkanes as Central Reagents in the Synthesis of Spiroketals. MOLECULES, 13, 319-330 [10.3390/molecules13020319].
Nitroalkanes as Central Reagents in the Synthesis of Spiroketals
ROSINI, GOFFREDO
2008
Abstract
Nitroalkanes can be profitably employed as carbanionic precursors for theassembly of dihydroxy ketone frameworks, suitable for the preparation of spiroketals. Thecarbon-carbon bond formation is carried out exploiting nitroaldol and Michael reactions,while the nitro to carbonyl conversion (Nef reaction) ensures the correct introduction of theketo group. Several spiroketal systems endowed with considerable biological activity canbe prepared using this synthetic strategy.File in questo prodotto:
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