Microcapsules containing ketoprofen were obtained by a spray drying process starting from a O/A emulsion in presence of different pH-sensitive materials (Eudragit® L100, Eudragit® S100 and stearic acid) dissolved in the external phase. The influence of formulation factors (oily phase employed for drug solubilisation, type of coating) on the morphology, particle size distribution, drug loading capacity, in-vitro release and ex-vivo permeation characteristics were investigated.
B. Luppi, F. Bigucci, T. Cerchiara, V. Zecchi (2008). pH-sensitive microcapsules of ketoprofen and mint essence for colon targeting.. s.l : s.n.
pH-sensitive microcapsules of ketoprofen and mint essence for colon targeting.
LUPPI, BARBARA;BIGUCCI, FEDERICA;CERCHIARA, TERESA;ZECCHI, VITTORIO
2008
Abstract
Microcapsules containing ketoprofen were obtained by a spray drying process starting from a O/A emulsion in presence of different pH-sensitive materials (Eudragit® L100, Eudragit® S100 and stearic acid) dissolved in the external phase. The influence of formulation factors (oily phase employed for drug solubilisation, type of coating) on the morphology, particle size distribution, drug loading capacity, in-vitro release and ex-vivo permeation characteristics were investigated.File in questo prodotto:
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